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Prevalence and genotype distribution of methicillin-resistant Staphylococcus aureus (MRSA) in India.印度耐甲氧西林金黄色葡萄球菌（MRSA）的流行情况和基因型分布。
J Glob Antimicrob Resist. 2016 Dec;7:46-52. doi: 10.1016/j.jgar.2016.07.008. Epub 2016 Aug 28.
2
Typing of Panton-Valentine Leukocidin-Encoding Phages and lukSF-PV Gene Sequence Variation in Staphylococcus aureus from China.中国金黄色葡萄球菌中潘顿-瓦伦丁杀白细胞素编码噬菌体的分型及lukSF-PV基因序列变异
Front Microbiol. 2016 Aug 3;7:1200. doi: 10.3389/fmicb.2016.01200. eCollection 2016.
3
Presence of the Panton-Valentine Leukocidin Genes in Methicillin-Resistant Staphylococcus aureus Is Associated with Severity and Clinical Outcome of Hospital-Acquired Pneumonia in a Single Center Study in China.在中国一项单中心研究中，耐甲氧西林金黄色葡萄球菌中潘顿-瓦伦丁杀白细胞素基因的存在与医院获得性肺炎的严重程度及临床结局相关。
PLoS One. 2016 Jun 1;11(6):e0156704. doi: 10.1371/journal.pone.0156704. eCollection 2016.
4
Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management.金黄色葡萄球菌感染：流行病学、病理生理学、临床表现及管理
Clin Microbiol Rev. 2015 Jul;28(3):603-61. doi: 10.1128/CMR.00134-14.
5
Panton-Valentine leukocidin (PVL)-positive health care-associated methicillin-resistant Staphylococcus aureus isolates are associated with skin and soft tissue infections and colonized mainly by infective PVL-encoding bacteriophages.与医疗保健相关的抗甲氧西林金黄色葡萄球菌分离株若携带杀白细胞素（PVL），则与皮肤和软组织感染有关，且主要由携带PVL编码基因的感染性噬菌体定植。
J Clin Microbiol. 2015 Jan;53(1):67-72. doi: 10.1128/JCM.01722-14. Epub 2014 Oct 22.
6
Dissemination of methicillin-resistant Staphylococcus aureus SCCmec type IV and SCCmec type V epidemic clones in a tertiary hospital: challenge to infection control.耐甲氧西林金黄色葡萄球菌IV型和V型葡萄球菌盒式染色体mec（SCCmec）流行克隆在一家三级医院的传播：对感染控制的挑战
Epidemiol Infect. 2015 Jan;143(2):343-53. doi: 10.1017/S095026881400065X. Epub 2014 Apr 2.
7
PATRIC, the bacterial bioinformatics database and analysis resource.PATRIC，细菌生物信息学数据库和分析资源。
Nucleic Acids Res. 2014 Jan;42(Database issue):D581-91. doi: 10.1093/nar/gkt1099. Epub 2013 Nov 12.
8
Pathogenesis of Staphylococcus aureus necrotizing pneumonia: the role of PVL and an influenza coinfection.金黄色葡萄球菌坏死性肺炎的发病机制：PVL 和流感合并感染的作用。
Expert Rev Anti Infect Ther. 2013 Oct;11(10):1041-51. doi: 10.1586/14787210.2013.827891. Epub 2013 Sep 27.
9
Staphylococcus aureus bacteremia in an Indian tertiary care hospital: observational study on clinical epidemiology, resistance characteristics, and carriage of the Panton-Valentine leukocidin gene.印度一家三级保健医院的金黄色葡萄球菌菌血症：临床流行病学、耐药特征和携带潘顿-瓦伦丁白细胞毒素基因的观察性研究。
Int J Infect Dis. 2013 Nov;17(11):e1051-5. doi: 10.1016/j.ijid.2013.06.002. Epub 2013 Jul 24.
10
Genome sequencing unveils a novel sea enterotoxin-carrying PVL phage in Staphylococcus aureus ST772 from India.基因组测序揭示了来自印度 ST772 型金黄色葡萄球菌中一种携带新型海洋肠毒素的 PVL 噬菌体。
PLoS One. 2013;8(3):e60013. doi: 10.1371/journal.pone.0060013. Epub 2013 Mar 27.

来自印度南部的携带杀白细胞素（PVL）毒素编码噬菌体的分子特征分析

Molecular characterization of Panton-Valentine leukocidin (PVL) toxin-encoding phages from South India.

作者信息

Balaji V, Yamuna D B, Francis Y I, Priya Doss G

机构信息

Department of Clinical Microbiology, Christian Medical College, Vellore, India.

Department of Integrative Biology, School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India.

出版信息

New Microbes New Infect. 2017 Aug 25;20:34-38. doi: 10.1016/j.nmni.2017.08.005. eCollection 2017 Nov.

DOI:10.1016/j.nmni.2017.08.005
PMID:29158906
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5682882/
Abstract

A total of 19 methicillin-resistant (MRSA) isolates were investigated for Panton-Valentine leukocidin (PVL) toxin, PVL gene sequence variation and PVL-encoding phages. Whole genome sequencing was performed for all isolates. Analysis of MRSA isolates ( = 19) confirmed that most MRSA ( = 11) were positive for the PVL gene and were multidrug resistant. ST772-MRSA-V was the predominant PVL-positive MRSA clone, although all of them were found to carry the ΦIND772PVL phage in the genome. This study provides insights into the evolution of a new lineage of PVL-MRSA and highlights the potential risk of the emergence of multidrug-resistant community-acquired MRSA with high virulence.

摘要

共对19株耐甲氧西林金黄色葡萄球菌（MRSA）分离株进行了杀白细胞素（PVL）毒素、PVL基因序列变异及编码PVL噬菌体的研究。对所有分离株进行了全基因组测序。对MRSA分离株（n = 19）的分析证实，大多数MRSA（n = 11）的PVL基因呈阳性且对多种药物耐药。ST772-MRSA-V是主要的PVL阳性MRSA克隆，尽管发现它们在基因组中均携带ΦIND772PVL噬菌体。本研究为PVL-MRSA新谱系的进化提供了见解，并突出了具有高毒力的多药耐药社区获得性MRSA出现的潜在风险。