Costantini Elisabetta, Illiano Ester, Giannitsas Konstantinos, Prestipino Marco, Pastore Antonio Luigi, Carbone Antonio, Palleschi Giovanni, Balsamo Raffaele, Natale Franca, Villari Donata, Bini Vittorio, Maruccia Serena, Filocamo Maria-Teresa, Zucchi Alessandro
Department of Surgical and Biomedical Sciences, Urology and Andrology Clinic, University of Perugia, Perugia, Italy.
Department of Urology, University of Patras School of Medicine, Patras University Hospital, Patras, Greece.
BJU Int. 2018 Mar;121(3):453-457. doi: 10.1111/bju.14081. Epub 2017 Dec 21.
To investigate the correlation of a history of lower urinary tract symptomatology during childhood with lower urinary tract dysfunction in young adult women.
This was a multicentre, prospective, case-control study conducted between April 2013 and November 2015. A total of 300 women, aged 18-40 years, participated. The case group comprised women attending urogynaecology clinics for various lower urinary tract complaints and the control group was recruited from a healthy population. Exclusion criteria were designed to avoid common causes of lower urinary tract dysfunction and symptoms and included diabetes mellitus, neurological disease and pelvic inflammatory disease. All women completed a self-administered 77-item questionnaire, exploring childhood urological and bowel history, as well as current urological, bowel and sexual symptoms. Statistical analysis was performed using chi-squared and Fisher's exact tests to compare categorical variables. Multivariate logistic regression models were fit for the prediction of the adult outcomes, incorporating as explanatory variables all those that showed a significant P value in bivariate analysis. P values < 0.05 were considered statistically significant.
Women with childhood urinary voiding and storage symptoms had a higher prevalence of these symptoms in adult life compared with women without such history. Women with urinary tract infections (UTIs) during childhood had a higher incidence of adult UTIs compared with women without this problem in childhood.
Lower urinary tract dysfunction in childhood seems to 'persist' in young adult life but the implications of this finding in clinical practice need to be defined in future studies.
探讨童年期下尿路症状史与年轻成年女性下尿路功能障碍之间的相关性。
这是一项于2013年4月至2015年11月进行的多中心、前瞻性病例对照研究。共有300名年龄在18至40岁之间的女性参与。病例组包括因各种下尿路问题就诊于泌尿妇科门诊的女性，对照组则从健康人群中招募。排除标准旨在避免下尿路功能障碍和症状的常见原因，包括糖尿病、神经系统疾病和盆腔炎。所有女性均完成了一份77项的自填问卷，内容涉及童年期泌尿系统和肠道病史，以及当前的泌尿系统、肠道和性症状。采用卡方检验和费舍尔精确检验进行统计分析，以比较分类变量。采用多变量逻辑回归模型预测成年后的结果，将在双变量分析中显示出显著P值的所有变量纳入作为解释变量。P值<0.05被认为具有统计学意义。
与无童年期排尿和储尿症状史的女性相比，有此类症状的女性在成年后出现这些症状的患病率更高。与童年期无尿路感染问题的女性相比，童年期有尿路感染（UTIs）的女性成年后UTIs的发病率更高。
童年期下尿路功能障碍似乎会在年轻成年期“持续存在”，但这一发现对临床实践的影响有待未来研究进一步明确。
