大鼠脊髓损伤后全身和局部细胞因子谱：多重分析
Systemic and Local Cytokine Profile following Spinal Cord Injury in Rats: A Multiplex Analysis.
作者信息
Mukhamedshina Yana O, Akhmetzyanova Elvira R, Martynova Ekaterina V, Khaiboullina Svetlana F, Galieva Luisa R, Rizvanov Albert A
机构信息
Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia.
Kazan State Medical University, Kazan, Russia.
出版信息
Front Neurol. 2017 Oct 31;8:581. doi: 10.3389/fneur.2017.00581. eCollection 2017.
Our study of the changes in cytokine profile in blood serum and in the spinal cord after traumatic spinal cord injury (SCI) has shown that an inflammatory reaction and immunological response are not limited to the CNS, but widespread. This fact was confirmed by changes detected in a cytokine profile in blood serum samples [MIP-1α, interleukin 1 (IL-1) α, IL-2, IL-5, IL-1β, MCP-1, RANTES]. There were also changes in the levels of MIP-1α, IL-1α, IL-2, IL-5, IL-18, GM-colony-stimulating factor, IL-17α, IFN-γ, IL-10, IL-13, MCP-1, and GRO KC CINC-1 in samples of the rat injured spinal cord. The results underscore the complex cytokine network imbalance exhibited after SCI and show significant changes in the concentrations of 14 cytokines/chemokines with different inflammatory and immunological activities.
我们对创伤性脊髓损伤（SCI）后血清和脊髓中细胞因子谱变化的研究表明，炎症反应和免疫反应并不局限于中枢神经系统，而是广泛存在。血清样本中细胞因子谱的变化[巨噬细胞炎性蛋白-1α（MIP-1α）、白细胞介素1（IL-1）α、IL-2、IL-5、IL-1β、单核细胞趋化蛋白-1（MCP-1）、调节激活正常T细胞表达和分泌因子（RANTES）]证实了这一事实。大鼠脊髓损伤样本中MIP-1α、IL-1α、IL-2、IL-5、IL-18、粒细胞-巨噬细胞集落刺激因子（GM-CSF）、IL-17α、干扰素-γ（IFN-γ）、IL-10、IL-13、MCP-1和生长调节致癌基因蛋白（GRO）、趋化因子（KC）、趋化因子（CINC-1）水平也发生了变化。这些结果强调了SCI后表现出的复杂细胞因子网络失衡，并显示出具有不同炎症和免疫活性的14种细胞因子/趋化因子浓度的显著变化。
Zotero 插件