Metabolic Bone Diseases Research Group, Nursing Department, University of Extremadura, 10003 Cáceres, Spain.
Int J Environ Res Public Health. 2017 Nov 23;14(12):1437. doi: 10.3390/ijerph14121437.
The bone is one of the relevant target organs of heavy metals, and heavy metal toxicity is associated with several degenerative processes, such osteoporosis and bone mineral alterations, that could lead to fractures. We aimed to study a presumed relationship between bone density, evaluated by quantitative bone ultrasound (QUS), dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) and the dietary intake of cadmium, lead and mercury in healthy premenopausal women. A total of 158 healthy, non-smoking, premenopausal women were incorporated into the study. A validated food frequency questionnaire (FFQ) was administered to assess intake during the preceding seven days. The median predicted dietary cadmium intake among the 158 women studied was 25.29 μg/day (18.62-35.00) and 2.74 μg/kg body weight/week (b.w./w) (1.92-3.83). Dietary lead intake was 43.85 μg/day (35.09-51.45) and 4.82 μg/kg b.w./w (3.67-6.13). The observed dietary mercury intake was 9.55 μg/day (7.18-13.57) and 1.02 μg/kg b.w./w (0.71-1.48). Comparisons, in terms of heavy metal intake, showed no significant results after further adjusting for energy intake. No statistically significant correlations between heavy metal intake and the QUS, DXA and pQCT parameters were observed. Levels of dietary exposure of cadmium, lead and mercury were mostly within the recommendations. We did not find associations between the QUS, DXA and pQCT parameters and the dietary intake of the studied heavy metals in healthy premenopausal women.
骨骼是重金属的相关靶器官之一，重金属毒性与几种退行性过程有关，如骨质疏松症和骨矿物质改变，这些都可能导致骨折。我们旨在研究通过定量骨超声（QUS）、双能 X 射线吸收法（DXA）和外周定量计算机断层扫描（pQCT）评估的骨密度与健康绝经前妇女的膳食镉、铅和汞摄入量之间的假定关系。共纳入 158 名健康、不吸烟的绝经前妇女进行研究。采用经过验证的食物频率问卷（FFQ）评估了前七天的饮食摄入量。在所研究的 158 名妇女中，中位数预测膳食镉摄入量为 25.29μg/天（18.62-35.00）和 2.74μg/kg 体重/周（b.w./w）（1.92-3.83）。膳食铅摄入量为 43.85μg/天（35.09-51.45）和 4.82μg/kg b.w./w（3.67-6.13）。观察到的膳食汞摄入量为 9.55μg/天（7.18-13.57）和 1.02μg/kg b.w./w（0.71-1.48）。进一步调整能量摄入后，重金属摄入量的比较结果无统计学意义。重金属摄入量与 QUS、DXA 和 pQCT 参数之间未观察到统计学上的显著相关性。镉、铅和汞的膳食暴露水平大多在推荐范围内。我们没有发现 QUS、DXA 和 pQCT 参数与健康绝经前妇女中研究重金属的膳食摄入量之间存在关联。
