Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
Curr Med Chem. 2018;25(26):3061-3073. doi: 10.2174/0929867325666171123202644.
From the past decade to date, several studies related to O-(2- [18F]fluoroethyl)-L-tyrosine (18F-FET) positron emission tomography (PET) in brain tumours have been published in the literature.
The aim of this narrative review is to summarize the recent developments and the current role of 18F-FET PET in brain tumours according to recent literature data.
Main findings from selected recently published and relevant articles on the role of 18F-FET PET in neuro-oncology are described.
18F-FET PET may be useful in the differential diagnosis between brain tumours and non-neoplastic lesions and between low-grade and high-grade gliomas. Integration of 18F-FET PET into surgical planning allows better delineation of the extent of resection beyond margins visible with standard MRI. For biopsy planning, 18F-FET PET is particularly useful in identifying malignant foci within non-contrast-enhancing gliomas. 18F-FET PET may improve the radiation therapy planning in patients with gliomas. This metabolic imaging method may be useful to evaluate treatment response in patients with gliomas and it improves the differential diagnosis between brain tumours recurrence and posttreatment changes. 18F-FET PET may provide useful prognostic information in high-grade gliomas.
Based on recent literature data 18F-FET PET may provide additional diagnostic information compared to standard MRI in neuro-oncology.
从过去十年到现在，已有多篇关于 O-(2-[(18)F]氟乙基)-L-酪氨酸（18F-FET）正电子发射断层扫描（PET）在脑肿瘤中的应用的研究在文献中发表。
本综述旨在根据最新文献数据总结 18F-FET PET 在脑肿瘤中的最新进展和当前作用。
描述了从最近发表的关于 18F-FET PET 在神经肿瘤学中作用的选定文章中提取的主要发现。
18F-FET PET 可用于脑肿瘤与非肿瘤性病变、低级别和高级别胶质瘤之间的鉴别诊断。将 18F-FET PET 纳入手术计划有助于更好地描绘标准 MRI 可见边缘之外的切除范围。对于活检计划，18F-FET PET 特别有助于识别非增强性胶质瘤中的恶性病灶。18F-FET PET 可改善接受放疗的胶质瘤患者的放疗计划。这种代谢成像方法可用于评估胶质瘤患者的治疗反应，并改善脑肿瘤复发与治疗后改变之间的鉴别诊断。18F-FET PET 可提供高级别胶质瘤的预后信息。
基于最新文献数据，18F-FET PET 在神经肿瘤学中与标准 MRI 相比可能提供额外的诊断信息。
