Ahmadalipour Ali, Ghodrati-Jaldbakhan Shahrbanoo, Samaei Seyed Afshin, Rashidy-Pour Ali
Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; Laboratory of Learning and Memory, Research Center and Department of Physiology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Laboratory of Learning and Memory, Research Center and Department of Physiology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran; Student Research Committee, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Neurobiol Learn Mem. 2018 Jan;147:54-64. doi: 10.1016/j.nlm.2017.11.013. Epub 2017 Nov 23.
Prenatal morphine exposure causes a variety of neurobehavioral alterations observed in later life. The present study investigated the effects of postnatal exercise and enriched environment (EE) on alterations in water maze learning and hippocampal long-term potentiation (LTP) and brain derived neurotrophic factor (BDNF) levels induced by exposure to morphine during prenatal period in rats. On gestation days 11-18, pregnant rats were injected twice daily with saline or morphine. Offspring were subjected to postnatal exercise and EE for 30 days and afterward, spatial learning and hippocampal LTP and BDNF levels were investigated. Prenatal morphine-exposure impaired the spatial learning and hippocampal LTP in both male and female offspring. Interestingly, postnatal exercise and EE increased performance in the water maze and improved LTP in both prenatally saline and morphine-exposed male and female rats. Prenatal morphine exposure also caused a reduction in the hippocampal BDNF levels in the female, but not male rats, and postnatal exercise and EE alleviated this deficit. Our results demonstrate that postnatal exercise and EE can improve deficits in water maze learning and hippocampal LTP and BDNF levels caused by prenatal morphine exposure.
产前暴露于吗啡会导致在后期生活中观察到的多种神经行为改变。本研究调查了产后运动和丰富环境（EE）对产前暴露于吗啡所致大鼠水迷宫学习、海马长时程增强（LTP）及脑源性神经营养因子（BDNF）水平改变的影响。在妊娠第11 - 18天，给怀孕大鼠每日注射两次生理盐水或吗啡。子代接受30天的产后运动和丰富环境处理，之后，研究其空间学习、海马LTP及BDNF水平。产前暴露于吗啡会损害雄性和雌性子代的空间学习及海马LTP。有趣的是，产后运动和丰富环境提高了在水迷宫中的表现，并改善了产前暴露于生理盐水和吗啡的雄性和雌性大鼠的LTP。产前暴露于吗啡还导致雌性而非雄性大鼠海马BDNF水平降低，产后运动和丰富环境减轻了这一缺陷。我们的结果表明，产后运动和丰富环境可改善产前暴露于吗啡所致的水迷宫学习、海马LTP及BDNF水平缺陷。
