Kim Sang Hoon, Kim Tae Bum, Kim Sang Heon, Park Heung Woo, Song Sook Hee, Jeong Jae Won, Jee Young Koo, Park Sang Won, Kim Mi Sun, Yoon Ho Joo
Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea.
Department of Internal Medicine, Eulji University Hospital, Seoul, Korea.
Allergy Asthma Immunol Res. 2018 Jan;10(1):88-94. doi: 10.4168/aair.2018.10.1.88.
The aim of this study was to examine the daily practice patterns of Symbicort® Maintenance and Reliever Therapy (SMART) in Korean asthmatic patients and to analyze clinical signs related to overuse. This study used an observational, multicenter, noninterventional, prospective, uncontrolled design for examining asthmatic patients prescribed SMART to assess the frequency and pattern of Symbicort® usage as a maintenance and reliever medication. The characteristics of patients showing signs of overuse (frequency of inhalation: 8 or more times per day) were also analyzed. Among the 1,518 patients analyzed, 1,292 (85.1%) completed the trial. The number of mean inhalations per day was 2.14±1.15; the number of patients who had at least 1 as needed usage (PRN) inhalation per day was 843 (55.5%); the mean frequency of PRN use was 0.25±0.67 inhalations per day. The number of patients who overused for at least 1 day was 260 (17.1%). In particular, young patients, patients with limited physical activity, and patients with nocturnal symptoms demonstrated high frequency of overuse. The frequency of overuse during SMART was not high in Korean asthmatic patients and the asthma status of follow-up outpatients improved overall. However, there is a need for careful education targeted toward younger patients, patients with limited physical activity, and patients with nocturnal symptoms owing to their tendency to frequently overuse.
本研究旨在调查韩国哮喘患者使用信必可都保®维持和缓解治疗（SMART）的日常使用模式，并分析与过度使用相关的临床体征。本研究采用观察性、多中心、非干预性、前瞻性、非对照设计，对开具了SMART的哮喘患者进行检查，以评估信必可都保®作为维持和缓解药物的使用频率和模式。还分析了出现过度使用迹象（吸入频率：每天8次或更多次）的患者特征。在分析的1518例患者中，1292例（85.1%）完成了试验。每日平均吸入次数为2.14±1.15；每天至少有1次按需使用（PRN）吸入的患者有843例（55.5%）；PRN使用的平均频率为每天0.25±0.67次吸入。至少有1天过度使用的患者有260例（17.1%）。特别是年轻患者、身体活动受限的患者和有夜间症状的患者过度使用频率较高。韩国哮喘患者在SMART期间的过度使用频率不高，随访门诊患者的哮喘状况总体有所改善。然而，由于年轻患者、身体活动受限的患者和有夜间症状的患者有频繁过度使用的倾向，需要针对他们进行仔细的教育。
