El-Assaad Iqbal, Al-Kindi Sadeer G, Aziz Peter F
Department of Pediatrics, Cleveland Clinic Children's, Cleveland, Ohio; and.
Department of Cardiology, Harrington Heart and Vascular Institute, University Hospitals and Case Western Reserve University, Cleveland, Ohio.
Pediatrics. 2017 Dec;140(6). doi: 10.1542/peds.2017-1438.
Previous estimates of sudden cardiac death in children and young adults vary significantly, and population-based studies in the United States are lacking. We sought to estimate the incidence, causes, and mortality trends of sudden cardiac death in children and young adults (1-34 years).
Demographic and mortality data based on death certificates for US residents (1-34 years) were obtained (1999-2015). Cases of sudden death and sudden cardiac death were retrieved by using the codes.
A total of 1 452 808 subjects aged 1 to 34 years died in the United States, of which 31 492 (2%) were due to sudden cardiac death. The estimated incidence of sudden cardiac death is 1.32 per 100 000 individuals and increased with age from 0.49 (1-10 years) to 2.76 (26-34 years). During the study period, incidence of sudden cardiac death declined from 1.48 to 1.13 per 100 000 ( < .001). Mortality reduction was observed across all racial and ethnic groups with a varying magnitude and was highest in children aged 11 to 18 years. Significant disparities were found, with non-Hispanic African American individuals and individuals aged 26 to 34 years having the highest mortality rates. The majority of young children (1-10 years) died of congenital heart disease ( = 1525, 46%), whereas young adults died most commonly from ischemic heart disease ( = 5075, 29%).
Out-of-hospital sudden cardiac death rates declined 24% from 1999 to 2015. Disparities in mortality exist across age groups and racial and ethnic groups, with non-Hispanic African American individuals having the highest mortality rates.
以往对儿童和青年人心源性猝死的估计差异很大，且美国缺乏基于人群的研究。我们试图估计儿童和青年（1 - 34岁）心源性猝死的发病率、病因及死亡率趋势。
获取了基于美国居民（1 - 34岁）死亡证明的人口统计学和死亡率数据（1999 - 2015年）。通过使用编码检索猝死和心源性猝死病例。
在美国，共有1452808名1至34岁的受试者死亡，其中31492人（2%）死于心源性猝死。心源性猝死的估计发病率为每10万人中有1.32例，且随年龄增长而增加，从0.49（1 - 10岁）增至2.76（26 - 34岁）。在研究期间，心源性猝死的发病率从每10万人1.48例降至1.13例（P < 0.001）。所有种族和族裔群体的死亡率均有所下降，但幅度不同，11至18岁儿童降幅最大。发现了显著差异，非西班牙裔非洲裔个体以及26至34岁个体的死亡率最高。大多数幼儿（1 - 10岁）死于先天性心脏病（n = 1525，46%），而青年最常见的死因是缺血性心脏病（n = 5075，29%）。
1999年至2015年，院外心源性猝死率下降了24%。不同年龄组以及种族和族裔群体之间存在死亡率差异，非西班牙裔非洲裔个体的死亡率最高。
