Bakhtiari Sedigheh, Azimi Somayyeh, Mehdipour Masoumeh, Amini Somayyeh, Elmi Zahra, Namazi Zahra
Associate Professor, Department of Oral medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Assistant Professor, Department of Oral medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Honorary Research Fellow, University of Western Australia, Perth, Australia.
J Dent Res Dent Clin Dent Prospects. 2015 Fall;9(4):281-4. doi: 10.15171/joddd.2015.049. Epub 2015 Dec 30.
Background and aims. Cigarette smoke can induce oral cancer by its free radicals and oxidative damage. Salivary anti-oxidants system is believed to have an important role in defense mechanisms against oxidative stress. This study was compared total antioxidant capacity (TAoC) of saliva in smokers and nonsmokers. Materials and methods . In this cross-sectional study, 30 male smokers with mean age of 45.23 years and 30 nonsmokers with mean age of 45.30 years participated. Unstimulated whole saliva samples were collected in the morning in two groups by spitting method. TAoC of saliva was measured with the special kit in two groups at the same time. Statistical analysis was performed by covariance test. Results. The mean salivary TAoC in nonsmokers (0.741±0.123 U/ml) was higher than that in smokers (0.529±0.167 U/ml). This difference was statistically significant (P<0.001). Conclusion. Smoking can alter salivary antioxidant capacity.
背景与目的。香烟烟雾可通过其自由基和氧化损伤诱发口腔癌。唾液抗氧化系统被认为在抵御氧化应激的防御机制中发挥重要作用。本研究比较了吸烟者和非吸烟者唾液的总抗氧化能力（TAoC）。材料与方法。在这项横断面研究中，30名平均年龄为45.23岁的男性吸烟者和30名平均年龄为45.30岁的非吸烟者参与其中。两组均于早晨通过吐唾法收集非刺激性全唾液样本。同时使用专用试剂盒测量两组唾液的TAoC。采用协方差检验进行统计分析。结果。非吸烟者唾液TAoC的平均值（0.741±0.123 U/ml）高于吸烟者（0.529±0.167 U/ml）。这种差异具有统计学意义（P<0.001）。结论。吸烟会改变唾液抗氧化能力。
