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氧化应激与前列腺疾病

Oxidative stress and prostatic diseases.

作者信息

Roumeguère Thierry, Sfeir Joseph, El Rassy Elie, Albisinni Simone, Van Antwerpen Pierre, Boudjeltia Karim Zouaoui, Farès Nassim, Kattan Joseph, Aoun Fouad

机构信息

Department of Urology, University Clinics of Brussels, Université Libre de Bruxelles, Erasme Hôpital, 187793 Bruxelles, Belgium.

Laboratory of Experimental Medicine, Unit 222, Université Libre de Bruxelles, Le Centre Hospitalier Universitaire de Charleroi, 6042 Charleroi, Belgium.

出版信息

Mol Clin Oncol. 2017 Nov;7(5):723-728. doi: 10.3892/mco.2017.1413. Epub 2017 Sep 19.

Abstract

Prostatic diseases are a common health problem among males in Western countries, and include chronic prostatic diseases, which have an unclear pathogenesis and few treatment options. and studies describe oxidative stress as a major pathway involved in the occurrence of benign prostatic hyperplasia, prostatic cancer and chronic prostatitis. Thus, the oxidative stress cascade is a potential target for the treatment of prostatic diseases. This paper presents a systematic review of the available data concerning the association between oxidative stress and the most common chronic prostatic diseases, and describes the available treatment options that act upon this pathway.

摘要

前列腺疾病是西方国家男性常见的健康问题,包括慢性前列腺疾病,其发病机制尚不明确,治疗选择有限。多项研究将氧化应激描述为参与良性前列腺增生、前列腺癌和慢性前列腺炎发生的主要途径。因此,氧化应激级联反应是治疗前列腺疾病的一个潜在靶点。本文对有关氧化应激与最常见慢性前列腺疾病之间关联的现有数据进行了系统综述,并描述了作用于该途径的现有治疗选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c76/5700279/5fbdaa98b63e/mco-07-05-0723-g00.jpg

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