Zhu Weizhen, Feng Dechao, Shi Xu, Wei Qiang, Yang Lu
Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Front Cell Dev Biol. 2022 Apr 20;10:850145. doi: 10.3389/fcell.2022.850145. eCollection 2022.
Overproduction of reactive oxygen species (ROS) and superlative lipid peroxidation promote tumorigenesis, and mitochondrial aldehyde dehydrogenase 2 (ALDH2) is associated with the detoxification of ROS-mediated lipid peroxidation-generated reactive aldehydes such as 4-hydroxy-2-nonenal (4-HNE), malondialdehyde, and acrolein due to tobacco smoking. ALDH2 has been demonstrated to be highly associated with the prognosis and chemoradiotherapy sensitivity of many types of cancer, including leukemia, lung cancer, head and neck cancer, esophageal cancer, hepatocellular cancer, pancreatic cancer, and ovarian cancer. In this study, we explored the possible relationship between ALDH2 and urological cancers from the aspects of ferroptosis, epigenetic alterations, proteostasis, mitochondrial dysfunction, and cellular senescence.
活性氧（ROS）的过度产生和脂质过氧化加剧促进肿瘤发生，线粒体醛脱氢酶2（ALDH2）与ROS介导的脂质过氧化产生的反应性醛（如4-羟基-2-壬烯醛（4-HNE）、丙二醛和丙烯醛）的解毒有关，吸烟会导致这些反应性醛的产生。已证明ALDH2与多种癌症的预后和放化疗敏感性高度相关，包括白血病、肺癌、头颈癌、食管癌、肝细胞癌、胰腺癌和卵巢癌。在本研究中，我们从铁死亡、表观遗传改变、蛋白质稳态、线粒体功能障碍和细胞衰老等方面探讨了ALDH2与泌尿系统癌症之间可能的关系。
