Epidemiology Unit, Istituto Dermopatico dell'Immacolata (IDI-IRCCS-FLMM), Via dei Monti di Creta, 104, 00167, Rome, Italy.
Medical Direction, Istituto Dermopatico dell'Immacolata (IDI-IRCCS-FLMM), Rome, Italy.
Arch Dermatol Res. 2018 Jan;310(1):71-76. doi: 10.1007/s00403-017-1799-z. Epub 2017 Nov 27.
It is well established that Androgenetic Alopecia (AGA) occurs in genetically predisposed individuals but little is known of its non-genetic risk factors. The aim of the study was to investigate the role of the Mediterranean diet in determining the risk of AGA. A hospital-based case-control study was conducted in the outpatient clinics of the hospital "Istituto Dermopatico dell'Immacolata, Rome, Italy". We included 104 males and 108 controls not affected by AGA. Controls were frequency matched to cases. Information on socio-demographic characteristics, medical history, smoking and diet were collected for all patients. Logistic regression was used to estimate odds ratio and 95% confidence intervals. After controlling for age, education, body mass index and family history of AGA, protective effects for AGA were found for high consumption (≥ 3 times weekly) of raw vegetables (OR 0.43; 95% CI 0.21-0.89) and high consumption of fresh herbs (3 or more regularly) (OR 0.44; 95% CI 0.22-0.87). We suggest that some foods of the Mediterranean diet, say fresh herbs and salad, may reduce the risk of AGA onset.
已经确定，雄激素性脱发（AGA）发生在遗传易感性个体中，但对其非遗传危险因素知之甚少。本研究旨在探讨地中海饮食在决定 AGA 风险中的作用。这是在意大利罗马“意大利免疫皮肤病学研究所”的门诊诊所进行的一项基于医院的病例对照研究。我们纳入了 104 名男性和 108 名未患 AGA 的对照者。对照者与病例按频率匹配。对所有患者收集了社会人口统计学特征、病史、吸烟和饮食信息。使用逻辑回归来估计比值比和 95%置信区间。在控制年龄、教育程度、体重指数和 AGA 家族史后，发现高摄入（每周≥3 次）生蔬菜（OR 0.43；95%CI 0.21-0.89）和高摄入新鲜香草（每 3 次或更多次）（OR 0.44；95%CI 0.22-0.87）对 AGA 具有保护作用。我们认为地中海饮食中的一些食物，如新鲜香草和沙拉，可能会降低 AGA 发病的风险。
