Choi Eun Ji, Cho Seong Beom, Lee Sa Ra, Lim Young Mi, Jeong Kyungah, Moon Hye-Sung, Chung Hyewon
Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans University, Seoul, Korea.
Division of Biomedical Informatics, Center for Genome Science, National Institute of Health, Korea Centers for Disease Control and Prevention (KCDC), Cheongju, Korea.
Obstet Gynecol Sci. 2017 Nov;60(6):579-586. doi: 10.5468/ogs.2017.60.6.579. Epub 2017 Oct 23.
Adenomyosis and endometriosis are relatively common gynecological diseases that exhibit many common features. This study identified gynecological and non-gynecological diseases that exhibited comorbidity with adenomyosis and endometriosis in Korean women.
We used Health Insurance Review and Assessment data from 2009 to 2011 and searched for adenomyosis and endometriosis (coded as N80.1 and D25 in International Classification of Disease, 10th revision [ICD-10], respectively). We selected records from patients who had independent disease occurrences in each year, and comorbidities were estimated using Fisher's exact test. We computed each year's similarities and combined 3 years' results using Fisher's -value summation method.
A total of 61,516 patients' data were collected during the study period. The prevalence of adenomyosis and endometriosis were similar each year: 12.4% and 9.3% in 2009, 12.5% and 9.4% in 2010 and 13.3% and 9.1% in 2011, respectively. Meta-analysis revealed that 31 ICD-10 codes were significantly related with adenomyosis, and 44 ICD-10 codes were related with endometriosis. Gynecological diseases, such as leiomyoma and benign ovarian tumor, were significantly related to adenomyosis and endometriosis. Non-gynecological diseases, such as anemia and hypercholesterolemia, were also related to adenomyosis and endometriosis.
We must monitor for the presence of gynecological and non-gynecological diseases with co-morbidities during evaluations and follow-up of patients with adenomyosis or endometriosis.
子宫腺肌病和子宫内膜异位症是较为常见的妇科疾病，具有许多共同特征。本研究确定了韩国女性中与子宫腺肌病和子宫内膜异位症合并存在的妇科和非妇科疾病。
我们使用了2009年至2011年的健康保险审查和评估数据，搜索子宫腺肌病和子宫内膜异位症（在国际疾病分类第10版[ICD-10]中分别编码为N80.1和D25）。我们从每年有独立疾病发生的患者记录中进行选择，并使用Fisher精确检验估计合并症。我们计算了每年的相似性，并使用Fisher P值求和法合并了3年的结果。
在研究期间共收集了61516例患者的数据。子宫腺肌病和子宫内膜异位症的患病率每年相似：2009年分别为12.4%和9.3%，2010年分别为12.5%和9.4%，2011年分别为13.3%和9.1%。荟萃分析显示，31个ICD-10编码与子宫腺肌病显著相关，44个ICD-10编码与子宫内膜异位症相关。妇科疾病，如子宫肌瘤和卵巢良性肿瘤，与子宫腺肌病和子宫内膜异位症显著相关。非妇科疾病，如贫血和高胆固醇血症，也与子宫腺肌病和子宫内膜异位症相关。
在对子宫腺肌病或子宫内膜异位症患者进行评估和随访时，我们必须监测是否存在合并症的妇科和非妇科疾病。
