Key Laboratory of Environmental Medicine Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, 87 Ding Jia Qiao Road, Nanjing 210009, China
Nutrients. 2017 Nov 24;9(12):1281. doi: 10.3390/nu9121281.
Red palm oil (RPO) has been investigated for preventing or alleviating vitamin A deficiency (VAD). Previous data has offered inconclusive and inconsistent results about the effects of RPO in patients with VAD. Our objective was to undertake a meta-analysis to assess the effects of RPO in preventing VAD in the population. After conducting a comprehensive literature search, nine randomized controlled trials (RCTs) were included. Overall, when trial results were pooled, the results indicated that RPO reduced the risk of VAD (relative risk (RR) (95% confidence interval (CI)) = 0.55 (0.37, 0.82), = 0.003), increasedserum retinol levels in both children ( < 0.00001) and adults ( = 0.002), and increased β-carotene levels ( = 0.01). However, RPO supplementation did not have a significant overall effect on serum α-carotene levels ( = 0.06), body weight ( = 0.45), and haemoglobin levels ( = 0.72). The results also showed that low level of PRO intake (≤8 g RPO) could increase serum retinol concentrations whereas PRO intake above 8 g did not lead to further increase of serum retinol concentrations. This meta-analysis demonstrated that RPO might be effective for preventing or alleviating VAD.
红棕榈油（RPO）已被研究用于预防或缓解维生素 A 缺乏症（VAD）。以前的数据对于 RPO 在 VAD 患者中的作用提供了不确定和不一致的结果。我们的目的是进行荟萃分析，以评估 RPO 在预防人群 VAD 中的作用。在进行全面的文献检索后，纳入了九项随机对照试验（RCT）。总体而言，当汇总试验结果时，结果表明 RPO 降低了 VAD 的风险（相对风险（RR）（95%置信区间（CI））= 0.55（0.37，0.82）， = 0.003），增加了儿童和成人血清视黄醇水平（ < 0.00001）（ = 0.002），并增加了 β-胡萝卜素水平（ = 0.01）。然而，RPO 补充剂对血清 α-胡萝卜素水平（ = 0.06）、体重（ = 0.45）和血红蛋白水平（ = 0.72）没有总体显著影响。结果还表明，低水平的 PRO 摄入（≤8 g RPO）可增加血清视黄醇浓度，而 PRO 摄入超过 8 g 不会导致血清视黄醇浓度进一步增加。这项荟萃分析表明，RPO 可能对预防或缓解 VAD 有效。
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