Leelakanok Nattawut, D'Cunha Ronilda R, Sutamtewagul Grerk, Schweizer Marin L
1 Faculty of Pharmaceutical Sciences, Burapha University, Chonburi, Thailand.
2 College of Pharmacy, University of Iowa, USA.
Nutr Health. 2018 Jun;24(2):121-131. doi: 10.1177/0260106018777170. Epub 2018 May 23.
Previous evidence supports that vitamin A decreases the risk of several types of cancer. However, the association between vitamin A and liver cancer is inconclusive.
This systematic review and meta-analysis summarizes the existing literature, discussing the association between vitamin A intake, serum vitamin A, and liver cancer in adult populations.
A systematic literature review was performed by searching the EMBASE, PubMed, Scopus and International Pharmaceutical Abstract databases using terms related to vitamin A (e.g. retinol, α-carotene, β-carotene, and β-cryptoxanthin) and hepatic cancer without applying any time restriction. A meta-analysis was performed using random effect models.
The meta-analysis of five studies showed no association between serum retinol and liver cancer (pooled risk ratio = 1.90 (0.40-9.02); n = 5 studies, I = 92%). In addition, the systematic review of studies from 1955 to July 2017 found studies that indicated no association between the intake and serum level of α-carotene ( n = 2) and β-cryptoxanthin ( n = 1) and the risk of liver cancer. Further, the associations between retinol intake ( n = 3), β-carotene intake ( n = 3), or serum β-carotene ( n = 3) and liver cancer were inconclusive.
Current information on the association between vitamin A intake and liver cancer or serum vitamin A and liver cancer are limited. Most studies demonstrated no association between dietary vitamin A and the risk of liver cancer. However, the finding was based on a small number of studies with potential publication bias. Therefore, large observational studies should be conducted to confirm these associations.
先前的证据支持维生素A可降低多种癌症的风险。然而，维生素A与肝癌之间的关联尚无定论。
本系统评价和荟萃分析总结现有文献，探讨成人人群中维生素A摄入量、血清维生素A与肝癌之间的关联。
通过检索EMBASE、PubMed、Scopus和国际药学文摘数据库，使用与维生素A相关的术语（如视黄醇、α-胡萝卜素、β-胡萝卜素和β-隐黄质）和肝癌，进行无时间限制的系统文献检索。使用随机效应模型进行荟萃分析。
五项研究的荟萃分析显示血清视黄醇与肝癌之间无关联（合并风险比=1.90（0.40-9.02）；n=5项研究，I=92%）。此外，对1955年至2017年7月的研究进行系统评价发现，有研究表明α-胡萝卜素（n=2）和β-隐黄质（n=1）的摄入量和血清水平与肝癌风险之间无关联。此外，视黄醇摄入量（n=3）、β-胡萝卜素摄入量（n=3）或血清β-胡萝卜素（n=3）与肝癌之间的关联尚无定论。
目前关于维生素A摄入量与肝癌或血清维生素A与肝癌之间关联的信息有限。大多数研究表明膳食维生素A与肝癌风险之间无关联。然而，这一发现基于少数可能存在发表偏倚的研究。因此，应开展大型观察性研究以证实这些关联。
