1 Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
2 Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Chron Respir Dis. 2018 Aug;15(3):250-257. doi: 10.1177/1479972317743759. Epub 2017 Nov 29.
Chronic obstructive pulmonary disease (COPD) has been described as a systemic disease. Sarcopenia is one of the systemic effects that is related to several adverse outcomes. The objectives of this study were to estimate the prevalence of sarcopenia and to determine the factors associated with sarcopenia in COPD patients in Southeast Asia. This was a cross-sectional study of COPD patients who attended a COPD clinic from May 2015 to December 2016. Baseline characteristics were collected and dual-energy X-ray absorptiometry was used to measure skeletal muscle mass. Handgrip strength was used to assess muscle strength, and as a measurement of physical performance, the 6-min walk distance was used. One hundred and twenty-one participants were recruited. Most of them were men (92.6%). Prevalence of sarcopenia was 24% (29 cases). Independent factors associated with sarcopenia were age ≥ 75 years (adjusted odds ratio (AOR) 13.3, severity of COPD (AOR 19.2 and 13.4 for moderate and severe COPD), Modified Medical Research Council (MMRC) scale (AOD 1.9), and obesity (AOR 0.04). Sarcopenia affects about one-quarter of COPD patients. Age, severity of COPD, MMRC scale, and BMI status were the factors associated with sarcopenia.
慢性阻塞性肺疾病（COPD）已被描述为一种全身性疾病。肌少症是与多种不良结局相关的全身性影响之一。本研究的目的是估计肌少症的患病率，并确定与东南亚 COPD 患者肌少症相关的因素。这是一项 COPD 患者的横断面研究，他们于 2015 年 5 月至 2016 年 12 月期间在 COPD 诊所就诊。收集了基线特征，并使用双能 X 线吸收法测量骨骼肌质量。手握力用于评估肌肉力量，并作为身体表现的测量，使用 6 分钟步行距离。共招募了 121 名参与者。他们大多数是男性（92.6%）。肌少症的患病率为 24%（29 例）。与肌少症相关的独立因素包括年龄≥75 岁（调整后的优势比（AOR）13.3）、COPD 严重程度（中重度 COPD 的 AOR 分别为 19.2 和 13.4）、改良医学研究委员会（MMRC）量表（AOD 1.9）和肥胖症（AOR 0.04）。肌少症影响了大约四分之一的 COPD 患者。年龄、COPD 严重程度、MMRC 量表和 BMI 状态是与肌少症相关的因素。
