Moghimi Jamileh, Ghahremanfard Farahnaz, Salari Maryam, Ghorbani Raheb
Social Determinants of Health Research Center, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Internal Medicine Department, Semnan University of Medical Sciences, Semnan, Iran.
Pan Afr Med J. 2017 Aug 14;27:276. doi: 10.11604/pamj.2017.27.276.12228. eCollection 2017.
In recent years, it is suggested that platelet histogram indices, such as mean platelet volume (MPV) may be related to the activity of rheumatoid arthritis (RA). The aim of this study was to assess relationship between MPV and activity of rheumatoid arthritis.
Sixty consecutive patients fulfilling the American College of Rheumatology (ACR) criteria for RA were recruited from the rheumatology outpatient clinics in Semnan, Iran. Current disease activity score (DAS-28 score) was assessed at baseline, 2 months and 4 months after the admission time and beginning of the treatment schedule. Complete blood count (including MPV), C-reactive protein (CRP) and ESR were measured in each visit. MPV was analyzed by the Cell Dyne 3500 automated blood cell counter.
There was a significant reduction in DAS-28 score within 4 months of total assessment (from 4.47 ± 2.24 versus 3.18 ± 1.55) (p < 0.001). There was no significant difference in MPV levels at the three study time points. No significant correlations were observed between the DAS-28 score and mean MPV levels at the same time points. The rate of positive CRP was decreased within the same period (p = 0.002); however, the trend of the changes in other laboratory parameters including MPV, platelet count and ESR values was not significant. The measurement of MPV value did not correlate with disease activity in RA patients within 4 months of treatment scheduling.
Although therapeutic regimens, which improve RA manifestations, can reduce RA activity, they had no effect on MPV during this time period. It seems MPV may not be able to predict disease activity in RA patients.
近年来，有研究表明血小板直方图指标，如平均血小板体积（MPV）可能与类风湿关节炎（RA）的活动有关。本研究旨在评估MPV与类风湿关节炎活动之间的关系。
从伊朗塞姆南的风湿病门诊连续招募了60例符合美国风湿病学会（ACR）类风湿关节炎标准的患者。在入院时和治疗方案开始后的2个月及4个月评估当前疾病活动评分（DAS-28评分）。每次就诊时均测量全血细胞计数（包括MPV）、C反应蛋白（CRP）和血沉（ESR）。MPV通过Cell Dyne 3500全自动血细胞计数器进行分析。
在整个评估的4个月内，DAS-28评分显著降低（从4.47±2.24降至3.18±1.55）（p<0.001）。在三个研究时间点，MPV水平无显著差异。在同一时间点，未观察到DAS-28评分与平均MPV水平之间存在显著相关性。同期CRP阳性率降低（p=0.002）；然而，包括MPV、血小板计数和ESR值在内的其他实验室参数的变化趋势不显著。在治疗计划的4个月内，MPV值的测量与RA患者的疾病活动无关。
虽然改善RA表现的治疗方案可降低RA活动度，但在此期间对MPV无影响。似乎MPV无法预测RA患者的疾病活动度。
