成人队列中脑时域近红外光谱技术：重现性分析、光学特性、血红蛋白种类及组织氧饱和度
Cerebral time domain-NIRS: reproducibility analysis, optical properties, hemoglobin species and tissue oxygen saturation in a cohort of adult subjects.
作者信息
Giacalone Giacomo, Zanoletti Marta, Contini Davide, Re Rebecca, Spinelli Lorenzo, Roveri Luisa, Torricelli Alessandro
机构信息
San Raffaele Scientific Institute, Neurology Department, Via Olgettina 60, 20132, Milan, Italy.
University "Vita-Salute" San Raffaele, Via Olgettina 60, 20132, Milan, Italy.
出版信息
Biomed Opt Express. 2017 Oct 12;8(11):4987-5000. doi: 10.1364/BOE.8.004987. eCollection 2017 Nov 1.
Abstract
The reproducibility of cerebral time-domain near-infrared spectroscopy (TD-NIRS) has not been investigated so far. Besides, reference intervals of cerebral optical properties, of absolute concentrations of deoxygenated-hemoglobin (HbR), oxygenated-hemoglobin (HbO), total hemoglobin (HbT) and tissue oxygen saturation (StO) and their variability have not been reported. We have addressed these issues on a sample of 88 adult healthy subjects. TD-NIRS measurements at 690, 785, 830 nm were fitted with the diffusion model for semi-infinite homogenous media. Reproducibility, performed on 3 measurements at 5 minutes intervals, ranges from 1.8 to 6.9% for each of the hemoglobin species. The mean ± SD global values of HbR, HbO, HbT, StO are respectively 24 ± 7 μM, 33.3 ± 9.5 μM, 57.4 ± 15.8 μM, 58 ± 4.2%. StO displays the narrowest range of variability across brain regions.
摘要
迄今为止，尚未对脑时域近红外光谱（TD-NIRS）的可重复性进行研究。此外，脑光学特性、脱氧血红蛋白（HbR）、氧合血红蛋白（HbO）、总血红蛋白（HbT）的绝对浓度以及组织氧饱和度（StO）的参考区间及其变异性也未见报道。我们针对88名成年健康受试者的样本解决了这些问题。在690、785、830纳米处的TD-NIRS测量值采用半无限均匀介质的扩散模型进行拟合。以5分钟为间隔进行3次测量的可重复性，对于每种血红蛋白种类而言，范围在1.8%至6.9%之间。HbR、HbO、HbT、StO的平均±标准差全局值分别为24±7微摩尔、33.3±9.5微摩尔、57.4±15.8微摩尔、58±4.2%。StO在各脑区显示出最窄的变异范围。
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