Giacalone Giacomo, Zanoletti Marta, Contini Davide, Re Rebecca, Spinelli Lorenzo, Roveri Luisa, Torricelli Alessandro
San Raffaele Scientific Institute, Neurology Department, Via Olgettina 60, 20132, Milan, Italy.
University "Vita-Salute" San Raffaele, Via Olgettina 60, 20132, Milan, Italy.
Biomed Opt Express. 2017 Oct 12;8(11):4987-5000. doi: 10.1364/BOE.8.004987. eCollection 2017 Nov 1.
The reproducibility of cerebral time-domain near-infrared spectroscopy (TD-NIRS) has not been investigated so far. Besides, reference intervals of cerebral optical properties, of absolute concentrations of deoxygenated-hemoglobin (HbR), oxygenated-hemoglobin (HbO), total hemoglobin (HbT) and tissue oxygen saturation (StO) and their variability have not been reported. We have addressed these issues on a sample of 88 adult healthy subjects. TD-NIRS measurements at 690, 785, 830 nm were fitted with the diffusion model for semi-infinite homogenous media. Reproducibility, performed on 3 measurements at 5 minutes intervals, ranges from 1.8 to 6.9% for each of the hemoglobin species. The mean ± SD global values of HbR, HbO, HbT, StO are respectively 24 ± 7 μM, 33.3 ± 9.5 μM, 57.4 ± 15.8 μM, 58 ± 4.2%. StO displays the narrowest range of variability across brain regions.
迄今为止，尚未对脑时域近红外光谱（TD-NIRS）的可重复性进行研究。此外，脑光学特性、脱氧血红蛋白（HbR）、氧合血红蛋白（HbO）、总血红蛋白（HbT）的绝对浓度以及组织氧饱和度（StO）的参考区间及其变异性也未见报道。我们针对88名成年健康受试者的样本解决了这些问题。在690、785、830纳米处的TD-NIRS测量值采用半无限均匀介质的扩散模型进行拟合。以5分钟为间隔进行3次测量的可重复性，对于每种血红蛋白种类而言，范围在1.8%至6.9%之间。HbR、HbO、HbT、StO的平均±标准差全局值分别为24±7微摩尔、33.3±9.5微摩尔、57.4±15.8微摩尔、58±4.2%。StO在各脑区显示出最窄的变异范围。
