An Lu, Wang Yuanyuan, Tian Qiwei, Yang Shiping
The Key Laboratory of Resource Chemistry of the Ministry of Education, the Shanghai Key Laboratory of Rare Earth Functional Materials, and the Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, China.
Materials (Basel). 2017 Nov 30;10(12):1372. doi: 10.3390/ma10121372.
Over the past few decades, the synthetic development of ultra-small nanoparticles has become an important strategy in nano-medicine, where smaller-sized nanoparticles are known to be more easily excreted from the body, greatly reducing the risk caused by introducing nano-theranostic agents. Gold nanorods are one of the most important nano-theranostic agents because of their special optical and electronic properties. However, the large size (diameter > 6 nm) of most obtained gold nanorods limits their clinical application. In recent years, more and more researchers have begun to investigate the synthesis and application of small gold nanorods (diameter < 6 nm), which exhibit similar optical and electronic properties as larger gold nanorods. In this review, we summarize the recent advances of synthesis of the small gold nanorods and their application for near-infrared light-mediated bio-imaging and cancer therapy.
在过去几十年中，超小纳米颗粒的合成发展已成为纳米医学中的一项重要策略，已知较小尺寸的纳米颗粒更容易从体内排出，从而大大降低引入纳米诊疗剂所带来的风险。金纳米棒因其特殊的光学和电子性质而成为最重要的纳米诊疗剂之一。然而，大多数获得的金纳米棒尺寸较大（直径>6 nm），这限制了它们的临床应用。近年来，越来越多的研究人员开始研究小尺寸金纳米棒（直径<6 nm）的合成与应用，其表现出与较大金纳米棒相似的光学和电子性质。在这篇综述中，我们总结了小尺寸金纳米棒合成的最新进展及其在近红外光介导的生物成像和癌症治疗中的应用。
