Danan Yossef, Yariv Inbar, Zalevsky Zeev, Sinvani Moshe
Faculty of Engineering, Bar-Ilan University, Ramat-Gan 5290002, Israel.
The Bar-Ilan Institute of Nanotechnology & Advanced Materials, Bar-Ilan University, Ramat-Gan 5290002, Israel.
Materials (Basel). 2017 Feb 20;10(2):203. doi: 10.3390/ma10020203.
Utilizing the surface plasmon resonance (SPR) effect of gold nanoparticles (GNPs) enables their use as contrast agents in a variety of biomedical applications for diagnostics and treatment. These applications use both the very strong scattering and absorption properties of the GNPs due to their SPR effects. Most imaging methods use the light-scattering properties of the GNPs. However, the illumination source is in the same wavelength of the GNPs' scattering wavelength, leading to background noise caused by light scattering from the tissue. In this paper we present a method to improve border detection of regions enriched with GNPs aiming for the real-time application of complete tumor resection by utilizing the absorption of specially targeted GNPs using photothermal imaging. Phantoms containing different concentrations of GNPs were irradiated with a continuous-wave laser and measured with a thermal imaging camera which detected the temperature field of the irradiated phantoms. By modulating the laser illumination, and use of a simple post processing, the border location was identified at an accuracy of better than 0.5 mm even when the surrounding area got heated. This work is a continuation of our previous research.
利用金纳米颗粒（GNPs）的表面等离子体共振（SPR）效应，可使其在多种用于诊断和治疗的生物医学应用中用作造影剂。这些应用利用了GNPs因其SPR效应而具有的极强散射和吸收特性。大多数成像方法利用GNPs的光散射特性。然而，照明源与GNPs的散射波长处于相同波长，导致组织光散射产生背景噪声。在本文中，我们提出了一种方法，旨在通过利用光热成像对特殊靶向GNPs的吸收，改进富含GNPs区域的边界检测，以实现完整肿瘤切除的实时应用。用连续波激光照射含有不同浓度GNPs的体模，并用热成像相机进行测量，该相机检测被照射体模的温度场。通过调制激光照明并使用简单的后处理，即使周围区域受热，边界位置的识别精度也能优于0.5毫米。这项工作是我们之前研究的延续。
