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铜催化氨基炔与炔的串联环化反应构建四氢吡咯并[1,2-a]喹啉骨架

A Copper-Catalyzed Tandem Cyclization Reaction of Aminoalkynes with Alkynes for the Construction of Tetrahydropyrrolo[1,2-a]quinolines Scaffold.

作者信息

Ma Can-Liang, Zhao Jin-Hao, Yang Yong, Zhang Min-Kui, Shen Chao, Sheng Rong, Dong Xiao-Wu, Hu Yong-Zhou

机构信息

Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.

Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Pesticide and Environmental Toxicology, Zhejiang University, Hangzhou, 310029, China.

出版信息

Sci Rep. 2017 Nov 30;7(1):16640. doi: 10.1038/s41598-017-16887-0.

Abstract

A synthetic method for diversely substituted tetrahydropyrrolo[1,2-a]quinolines was developed via CuCl-catalyzed cascade transformation of internal aminoalkynes with alkynes under microwave- irradiation.

摘要

通过微波辐射下氯化铜催化的内氨基炔烃与炔烃的串联转化,开发了一种合成多种取代四氢吡咯并[1,2-a]喹啉的方法。

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