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A novel aldehyde dehydrogenase-3 activator leads to adult salivary stem cell enrichment in vivo.一种新型醛脱氢酶-3 激活剂可在体内诱导成人唾液干细胞富集。
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CD29 在人唾液腺的上皮细胞、肌上皮细胞和间充质基质细胞上高度表达。

CD29 is highly expressed on epithelial, myoepithelial, and mesenchymal stromal cells of human salivary glands.

机构信息

Blood Systems Research Institute, San Francisco, CA, USA.

Division of Head and Neck Oncologic/Endocrine/Salivary Surgery, Department of Otolaryngology, University of California San Francisco, San Francisco, CA, USA.

出版信息

Oral Dis. 2018 May;24(4):561-572. doi: 10.1111/odi.12812. Epub 2018 Mar 13.

DOI:10.1111/odi.12812
PMID:29197149
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5902634/
Abstract

OBJECTIVE

The phenotype of the cells present in the ductal region of salivary glands has been well characterized. However, it is imperative to identify novel biomarkers that can identify different cell types present in other glandular components for the development of therapeutic strategies and diagnostics of salivary gland disorders and malignancies. Our study aimed at the characterization of the expression and distribution of various cell surface markers, especially with a focus on CD29 in human fetal as well as adult glands.

MATERIALS AND METHODS

Paired human midgestation fetal and adult parotid, sublingual, and submandibular glands were collected. Phenotypic expression of various lineage-specific cell surface markers including CD29 was investigated in freshly collected glands. The findings were further corroborated by immunohistochemistry.

RESULTS

Enriched expression of CD29 was found on acinar and ductal epithelial, mesenchymal stromal, and myoepithelial cells; CD29 cells co-expressed epithelial (CD324, CD326, NKCC1, and CD44), mesenchymal (CD73, CD90, vimentin, and CD34), and myoepithelial (α-SMA) cell-specific progenitor markers in both fetal as well as adult salivary glands.

CONCLUSION

CD29 is widely expressed in human salivary glands, and it could serve as a potential biomarker for devising novel cellular therapeutic and diagnostic strategies for salivary gland disorders and malignancies.

摘要

目的

唾液腺导管区细胞的表型已得到很好的描述。然而，确定能够识别其他腺体成分中不同细胞类型的新型生物标志物对于开发唾液腺疾病和恶性肿瘤的治疗策略和诊断方法至关重要。我们的研究旨在表征各种细胞表面标志物的表达和分布，特别是重点研究 CD29 在人胎儿和成人腺体中的表达和分布。

材料和方法

收集配对的人中期胎儿和成人腮腺、舌下腺和颌下腺。在新鲜采集的腺体中研究了各种谱系特异性细胞表面标志物（包括 CD29）的表型表达。免疫组织化学进一步证实了这些发现。

结果

在腺泡和导管上皮细胞、间充质基质细胞和肌上皮细胞上发现了丰富的 CD29 表达；CD29 细胞在胎儿和成人唾液腺中共同表达上皮细胞（CD324、CD326、NKCC1 和 CD44）、间充质细胞（CD73、CD90、波形蛋白和 CD34）和肌上皮细胞（α-SMA）特异性祖细胞标志物。

结论

CD29 在人唾液腺中广泛表达，它可以作为设计唾液腺疾病和恶性肿瘤新型细胞治疗和诊断策略的潜在生物标志物。