早期生活社会经济地位与乳腺癌发病和死亡的关联：系统评价。
The association of early life socioeconomic position on breast cancer incidence and mortality: a systematic review.
机构信息
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA.
出版信息
Int J Public Health. 2018 Sep;63(7):787-797. doi: 10.1007/s00038-017-1060-8. Epub 2017 Dec 2.
OBJECTIVES
We conducted a systematic review of the literature relating early life socioeconomic position (SEP) to breast cancer incidence and mortality from a critical period and life-course trajectory perspective.
METHODS
PubMed, EMBASE and Web of Science were searched to identify cohort studies that evaluated the impact of early life SEP indicators on the incidence and/or mortality from breast cancer in adulthood.
RESULTS
Nine distinct studies evaluated the relationship between early life SEP and breast cancer between 1990 and 2016. Five reports assessed breast cancer incidence and five assessed breast cancer mortality as outcomes; one study assessed both incidence and mortality. While lower early life SEP was associated with reduced breast cancer incidence and increased breast cancer mortality in the US, studies conducted in Europe were unable to establish a consistent association.
CONCLUSIONS
We found moderate support for the association between early life SEP and incidence and mortality from breast cancer. The impact of early life SEP on breast cancer incidence and mortality appeared to vary between countries. We urge further investigation of the role of lifelong SEP trajectories in breast cancer outcomes.
目的
我们从关键时期和生命轨迹的角度，对与早期社会经济地位（SEP）与乳腺癌发病率和死亡率相关的文献进行了系统评价。
方法
通过检索 PubMed、EMBASE 和 Web of Science，确定了评估早期 SEP 指标对成年期乳腺癌发病率和/或死亡率影响的队列研究。
结果
9 项不同的研究评估了 1990 年至 2016 年间早期 SEP 与乳腺癌之间的关系。5 项报告评估了乳腺癌发病率，5 项评估了乳腺癌死亡率为结局；一项研究评估了发病率和死亡率。虽然较低的早期 SEP 与美国乳腺癌发病率降低和死亡率增加相关，但在欧洲进行的研究未能建立一致的关联。
结论
我们发现早期 SEP 与乳腺癌发病率和死亡率之间存在中等程度的关联。早期 SEP 对乳腺癌发病率和死亡率的影响似乎因国家而异。我们敦促进一步研究终身 SEP 轨迹在乳腺癌结局中的作用。
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