Division of Oncology, Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University, Martin, Slovakia.
Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Comenius University and University Hospital, Bratislava, Slovakia.
Biomed Pharmacother. 2017 Dec;96:1465-1477. doi: 10.1016/j.biopha.2017.11.134. Epub 2017 Dec 1.
Breast cancer is the most common malignancy in women worldwide. Over 90% of all breast cancer cases are of different 'sporadic' cell types, thus placing emphasis on the need for breast cancer prevention and new effective treatment strategies. In recent years, pre-clinical research provides growing evidence regarding the beneficial action of bioactive plant-derived substances - phytochemicals, on multiple cancer-related biological pathways. The important natural source of various phytochemicals with anti-oncogenic properties are plant-based functional foods. It is hypothesized that a significant anti-tumour activity of plant-based functional foods are the result of a combination of various phytochemicals rather than an isolated agent. The mixture of phytochemicals with various biological activities present in whole foods could have additive or synergistic effects against carcinogenesis. Clinically, it is very important to compare the effect of the isolated phytochemicals against the mixture of phytochemicals present in specific plant-based functional foods. Therefore, the purpose of this review article is to compare anticancer activities of isolated phytochemicals and plant-based functional foods for the prevention and therapy of breast carcinoma. Our conclusion supports the hypothesis that a mixture of wide range of phytochemicals with a plethora of biological activities present in whole plant-derived foods could have additive or synergistic effects against breast cancer. Although, the lack of parallel comparative studies between whole natural foods versus isolated plant compounds limits our conclusion, future pre-clinical and clinical studies evaluating this issue is required.
乳腺癌是全世界女性最常见的恶性肿瘤。超过 90%的乳腺癌病例属于不同的“散发性”细胞类型，因此强调了乳腺癌预防和新的有效治疗策略的必要性。近年来，临床前研究为生物活性植物衍生物质——植物化学物质对多种与癌症相关的生物途径的有益作用提供了越来越多的证据。具有抗肿瘤特性的各种植物化学物质的重要天然来源是植物性功能性食品。人们假设，植物性功能性食品的显著抗肿瘤活性是各种植物化学物质组合的结果，而不是单一物质的结果。各种具有不同生物活性的植物化学物质的混合物可能对致癌作用具有相加或协同作用。在临床上，比较分离的植物化学物质与特定植物性功能性食品中存在的植物化学物质混合物的效果非常重要。因此，本文的目的是比较分离的植物化学物质和植物性功能性食品在预防和治疗乳腺癌方面的抗癌活性。我们的结论支持这样一种假设，即广泛存在于全植物源性食品中的具有多种生物活性的多种植物化学物质的混合物可能对乳腺癌具有相加或协同作用。尽管缺乏全天然食品与分离植物化合物之间的平行对照研究限制了我们的结论，但需要进行未来的临床前和临床研究来评估这个问题。
