Ren Qing, Zhao Ruibin, Wang Cheng, Li Shangge, Zhang Tingting, Ren Zongming, Yang Meiyi, Pan Hongwei, Xu Shiguo, Zhu Jianping, Wang Xun
Institute of Environment and Ecology, Shandong Normal University, Jinan 250014, China.
Management College, Ocean University of China, Qingdao 266100, China.
J Toxicol. 2017;2017:3265727. doi: 10.1155/2017/3265727. Epub 2017 Oct 19.
The unpredictable toxicity of insecticides may cause behavior disorder of biological organisms. In order to assess the role of acetylcholinesterase (AChE) in swimming behavior of , a correlation analysis of both parameters in 24 h exposure of deltamethrin (DM) and methomyl (MT) was investigated. The behavior responses of in DM (13.36 g/L and 33.40 g/L) and MT (19.66 g/L and 49.15 g/L) suggested that recovery behavior in the adjustment phase was crucial, and behavior homeostasis provided them with an optimal way to achieve a wider tolerance against environmental stress. During the experiment, positive effects on AChE activity occurred in the beginning of the exposure. Even though the de novo synthesis of AChE in might help it recover, the AChE inhibition in different treatments could be observed. Some induction effects on AChE activity at the beginning of exposure occurred, and a 50% decrease may cause toxic effects on behavior. In most treatments, the results showed that both behavior strength and AChE activity stayed in the same field within a correlation circle. These results illustrated that the environmental stress caused by both DM and MT could inhibit AChE activity and subsequently induce a stepwise behavior response, though both pesticides affect it as direct and indirect inhibitors, respectively.
杀虫剂不可预测的毒性可能导致生物有机体的行为紊乱。为了评估乙酰胆碱酯酶（AChE）在[生物名称]游泳行为中的作用，研究了溴氰菊酯（DM）和灭多威（MT）24小时暴露下这两个参数的相关性分析。[生物名称]在DM（13.36 g/L和33.40 g/L）和MT（19.66 g/L和49.15 g/L）中的行为反应表明，调整阶段的恢复行为至关重要，行为稳态为它们提供了一种实现对环境压力更广泛耐受性的最佳方式。在实验过程中，暴露开始时对AChE活性产生了积极影响。尽管[生物名称]中AChE的从头合成可能有助于其恢复，但在不同处理中仍可观察到AChE受到抑制。暴露开始时对AChE活性产生了一些诱导作用，AChE活性降低50%可能会对行为产生毒性影响。在大多数处理中，结果表明行为强度和AChE活性在一个相关圈内处于同一范围。这些结果说明，DM和MT引起的环境压力均可抑制AChE活性，进而诱导逐步的行为反应，尽管这两种农药分别作为直接和间接抑制剂对其产生影响。
