Zeydabadi Nejad Sareh, Ramezani Tehrani Fahimeh, Zadeh-Vakili Azita
Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Int J Endocrinol Metab. 2017 Apr 22;15(3):e44337. doi: 10.5812/ijem.44337. eCollection 2017 Jul.
Kisspeptin (KISS1), a recently discovered neuropeptide that acts upstream of gonadotropin-releasing hormone (GnRH) neurons, is critical for maturation and function of the reproductive axis. This review aimed at providing comprehensive and up-to-date information on Kisspeptin and its role in female reproduction.
A literature review was performed using PubMed for all English language articles published between 1999 and 2016.
The kisspeptin system (KISS1/G protein-coupled receptor-54,GPR54) has recently been addressed as an essential gatekeeper of puberty onset and gonadotropin secretion. Compelling evidence has documented that hypothalamic Kisspeptin mediates steroid feedback and metabolic cues at different developmental stages throughout lifespan. Furthermore, in pre/postnatally androgenized animal models, which exhibit many of the characteristics of Polycystic Ovarian Syndrome (PCOS), the hypothalamic expression of KISS1 and GnRH is abnormal, which might lead to multiple tissue abnormalities observed in this disorder.
Kisspeptin, a principal activator of GnRH neurons and the target of endocrine and metabolic cues, is a prerequisite for the onset of puberty and maintenance of normal reproductive function, as abnormal KISS1/GPR54 system has been reported in both animal models and patients with certain forms of infertility, e.g. Idiopathic Hypogonadotropic hypogonadism (IHH) and PCOS. The information suggests that kisspeptin or its receptor represents a potential therapeutic target in the treatment of patients with fertility disorders.
kisspeptin（KISS1）是一种最近发现的神经肽，作用于促性腺激素释放激素（GnRH）神经元的上游，对生殖轴的成熟和功能至关重要。本综述旨在提供关于kisspeptin及其在女性生殖中作用的全面和最新信息。
使用PubMed对1999年至2016年发表的所有英文文章进行文献综述。
kisspeptin系统（KISS1/G蛋白偶联受体54，GPR54）最近被认为是青春期启动和促性腺激素分泌的重要守门人。有力证据表明，下丘脑kisspeptin在整个生命周期的不同发育阶段介导类固醇反馈和代谢信号。此外，在产前/产后雄激素化的动物模型中，这些模型表现出多囊卵巢综合征（PCOS）的许多特征，KISS1和GnRH的下丘脑表达异常，这可能导致该疾病中观察到的多种组织异常。
kisspeptin是GnRH神经元的主要激活剂以及内分泌和代谢信号的靶点，是青春期启动和维持正常生殖功能的先决条件，因为在动物模型和某些形式不孕症患者（如特发性低促性腺激素性性腺功能减退（IHH）和PCOS）中均已报道KISS1/GPR54系统异常。这些信息表明，kisspeptin或其受体是治疗生育障碍患者的潜在治疗靶点。
