Nagaya T, Ishikawa N, Hata H
Department of Public Health, Gifu University School of Medicine, Japan.
Br J Ind Med. 1989 Jan;46(1):48-51. doi: 10.1136/oem.46.1.48.
To investigate the usefulness of sister chromatid exchange (SCE) analysis in lymphocytes as an indicator for mutagenic effects after in vivo exposure to hexavalent chromium (Cr), SCE frequency was analysed in lymphocytes of 44 Cr platers occupationally exposed to hexavalent Cr and 47 controls. Although urinary Cr analysis confirmed that the Cr platers were exposed to Cr, no effects of the exposure on SCE frequency were found. Smokers, both Cr platers and controls, had a significantly higher SCE frequency than non-smokers. These results suggest that SCE analysis in human lymphocytes is not a good indicator of possible mutagenic effects of exposure to hexavalent Cr.
为了研究淋巴细胞中姐妹染色单体交换（SCE）分析作为体内暴露于六价铬（Cr）后诱变效应指标的有用性，对44名职业性接触六价铬的镀铬工人和47名对照者的淋巴细胞进行了SCE频率分析。尽管尿铬分析证实镀铬工人接触了铬，但未发现接触对SCE频率有影响。镀铬工人和对照者中的吸烟者，其SCE频率均显著高于不吸烟者。这些结果表明，人淋巴细胞中的SCE分析并非接触六价铬可能产生诱变效应的良好指标。
