Nagaya T, Ishikawa N, Hata H, Takahashi A, Yoshida I, Okamoto Y
Department of Public Health, Gifu University School of Medicine, Japan.
Arch Toxicol. 1994;68(5):322-4. doi: 10.1007/s002040050076.
To detect early renal effects of occupational exposure to hexavalent chromium (Cr), urinary total proteins (U-TP), urinary albumin (U-Alb) and urinary retinol-binding protein (U-RBP) were determined in 166 male Cr platers and 106 male controls. The mean employment time in Cr plating for the platers was 12.6 years. Urinary Cr (U-Cr), which was determined as an index of Cr exposure, ranged from "not detected" to 19.91 micrograms/g creatinine in the platers. The U-Cr level was lower than those in other previous studies. Age-adjusted U-TP, U-Alb or U-RBP levels were not different between the platers and the controls. In the platers, a significant positive correlation was found between age-adjusted U-TP and U-Cr, but U-Cr had no significant relation to age-adjusted U-Alb or U-RBP level. Employment time had no effect on any age-adjusted urinary proteins. The Cr exposure may have been too low to induce definite renal dysfunction. Early renal effects of low-level Cr exposure may be mild, and may not be specific to renal function.
为检测职业性接触六价铬（Cr）对肾脏的早期影响，对166名男性镀铬工人和106名男性对照者测定了尿总蛋白（U-TP）、尿白蛋白（U-Alb）和尿视黄醇结合蛋白（U-RBP）。镀铬工人的平均镀铬工作时间为12.6年。作为铬暴露指标的尿铬（U-Cr）在镀铬工人中范围为“未检测到”至19.91微克/克肌酐。U-Cr水平低于以往其他研究中的水平。经年龄调整后的U-TP、U-Alb或U-RBP水平在镀铬工人和对照者之间无差异。在镀铬工人中，经年龄调整后的U-TP与U-Cr之间存在显著正相关，但U-Cr与经年龄调整后的U-Alb或U-RBP水平无显著关系。工作时间对任何经年龄调整后的尿蛋白均无影响。铬暴露可能过低，不足以诱发明确的肾功能障碍。低水平铬暴露对肾脏的早期影响可能较轻微，且可能并非肾功能所特有。
