感染与疾病的人类基因组学
Human Genomics of Infection and Disease.
作者信息
Orlova Marianna, Schurr Erwin
机构信息
Program in Infectious Diseases and Immunity in Global Health, The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
McGill International TB Centre, McGill University, Montreal, Quebec, Canada.
出版信息
Curr Genet Med Rep. 2017 Sep;5(3):125-131. doi: 10.1007/s40142-017-0124-7. Epub 2017 Jul 25.
PURPOSE OF REVIEW
The study of the genetic basis of tuberculosis pathogenesis has benefited from powerful technological innovations, a more structured definition of latent and clinical manifestations of the disease, and the application of functional genomics approaches. This short review aims to summarize recent advances and to provide a link with results of previous human genetic studies of tuberculosis susceptibility.
RECENT FINDINGS
Transcriptomics has been shown to be a useful tool to predict progression from latency to clinical disease while functional genomics has traced the molecular events that link pathogen-triggered gene expression and host genetics. Resistance to infection with has been revealed to be strongly impacted by host genetics. Host genomics of clinical disease has been shown to be most powerful when focusing on carefully selected clinical entities and possibly by considering host pathogen combinations.
SUMMARY
Future studies need to build on the latest molecular findings to define disease subtypes to successfully elucidate the human genetic component in tuberculosis pathogenesis.
综述目的
结核病发病机制的遗传基础研究受益于强大的技术创新、对该疾病潜伏和临床表现更结构化的定义以及功能基因组学方法的应用。这篇简短综述旨在总结近期进展，并将其与先前关于结核病易感性的人类遗传学研究结果建立联系。
近期发现
转录组学已被证明是预测从潜伏状态进展到临床疾病的有用工具，而功能基因组学已追踪到将病原体触发的基因表达与宿主遗传学联系起来的分子事件。已发现对感染的抵抗力受到宿主遗传学的强烈影响。临床疾病的宿主基因组学在专注于精心挑选的临床实体并可能考虑宿主病原体组合时显示出最强的作用。
总结
未来的研究需要基于最新的分子发现来定义疾病亚型，以成功阐明结核病发病机制中的人类遗传成分。
Zotero 插件