巴基斯坦成年人溃疡性结肠炎的临床表现

Clinical Presentation of Ulcerative Colitis in Pakistani Adults.

作者信息

Qureshi Mustafa, Abbas Zaigham

机构信息

Department of Medicine, Orthopedic and Medical Institute, Karachi, Pakistan.

出版信息

Euroasian J Hepatogastroenterol. 2015 Jul-Dec;5(2):127-130. doi: 10.5005/jp-journals-10018-1151. Epub 2016 Jul 9.

DOI:10.5005/jp-journals-10018-1151

PMID:29201709

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5578543/

Abstract

OBJECTIVE

The aim of this study was to determine the clinical presentation and severity of ulcerative colitis (UC) in Pakistani adult patients.

MATERIALS AND METHODS

An observational study. Data were obtained by reviewing the medical records of patients who visited a gastroenterology clinic between 2008 and 2012.

RESULTS

There were 54 patients diagnosed as UC. The male to female ratio was 1:1. Mean age at diagnosis of UC was 38.7 ± 11.8 years (median 36.5, range 18-64). The predominant presenting symptoms were mucus diarrhea in 49 (90.7%), gross blood in stools in 42 (77.8%), abdominal pain or cramps in 40 (74.1%) and weight loss in 15 (27.7%). Left-sided colitis was present in 23 (42.6%), pancolitis in 15 (27.8%), extensive colitis in 11 (20.4%), and proctitis in five (9.2%). The severity of UC as judged by the Mayo scoring system showed that 68.5% were suffering from moderate to severe disease while 31.5% had mild disease. The extra-intestinal manifestation were found only in seven patients; arthritis in five patients and anterior uveitis in two patients. The arthritis was unilateral and the sites were knee joint in three patients and sacroiliac joint in two patients.

CONCLUSION

Ulcerative colitis presents in our adult patients may present at any age with no gender preponderance. The disease severity is moderate to severe in the majority of patients and more than half of them have left-sided colitis or pancolitis at the time of presentation. Extraintestinal manifestations were not common.

HOW TO CITE THIS ARTICLE

Qureshi M, Abbas Z. Clinical Presentation of Ulcerative Colitis in Pakistani Adults. Euroasian J Hepato-Gastroenterol 2015;5(2):127-130.

摘要

目的

本研究旨在确定巴基斯坦成年溃疡性结肠炎（UC）患者的临床表现及严重程度。

材料与方法

一项观察性研究。通过查阅2008年至2012年间就诊于胃肠病诊所患者的病历获取数据。

结果

共54例患者被诊断为UC。男女比例为1:1。UC诊断时的平均年龄为38.7±11.8岁（中位数36.5岁，范围18 - 64岁）。主要的首发症状为黏液便腹泻49例（90.7%）、便血42例（77.8%）、腹痛或痉挛40例（74.1%）以及体重减轻15例（27.7%）。左半结肠炎23例（42.6%）、全结肠炎15例（27.8%）、广泛性结肠炎11例（20.4%）以及直肠炎5例（9.2%）。根据梅奥评分系统判断，UC的严重程度显示68.5%的患者患有中度至重度疾病，而31.5%为轻度疾病。肠外表现仅在7例患者中发现；5例患者有关节炎，2例患者有前葡萄膜炎。关节炎为单侧，3例患者累及膝关节，2例患者累及骶髂关节。