12-表-9-去乙酰氧基异西尼辛，一种来自婆罗洲软珊瑚Xenia sp.的新型细胞毒性二萜类化合物
12-Epi-9-deacetoxyxenicin, new cytotoxic diterpenoid from a Bornean soft coral, Xenia sp.
作者信息
Phan Chin-Soon, Kamada Takashi, Ishii Takahiro, Hamada Toshiyuki, Vairappan Charles Santhanaraju
机构信息
a Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation , Universiti Malaysia Sabah , Kota Kinabalu , Malaysia.
b Faculty of Agriculture, Department of Bioscience and Biotechnology , University of the Ryukyus , Nishihara , Japan.
出版信息
Nat Prod Res. 2019 Mar;33(6):808-813. doi: 10.1080/14786419.2017.1410812. Epub 2017 Dec 5.
One new compound, 12-epi-9-deacetoxyxenicin (1) along with a hydroperoxide product, 12-epi-9-deacetoxy-8-hydroperoxyxenicin (2) and two known sesquiterpenoids (3-4) were isolated from a population of Bornean soft coral Xenia sp. The structures of these secondary metabolites were elucidated based on their spectroscopic data. Compounds 1 and 2 showed cytotoxic activity against ATL cell line, S1T. In addition, compound 3 exhibited hyphal inhibition of Lagenidium thermophilum.
从婆罗洲软珊瑚Xenia sp.群体中分离出一种新化合物12-表-9-去乙酰氧基西尼辛（1），以及一种氢过氧化物产物12-表-9-去乙酰氧基-8-氢过氧化西尼辛（2）和两种已知的倍半萜（3 - 4）。这些次生代谢产物的结构通过光谱数据得以阐明。化合物1和2对成人T细胞白血病细胞系S1T显示出细胞毒性活性。此外，化合物3对嗜热拉格孢表现出菌丝抑制作用。
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