Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia.
Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Korea.
Mar Drugs. 2018 Mar 21;16(4):99. doi: 10.3390/md16040099.
Soft corals are known to be prolific producers of a wide spectrum of biologically active cembranoids. One new cembranoid, sinularolide F (), along with three known compounds, cembranolide (), (,,)-6,10,14-trimethyl-3-methylene--3α,4,5,8,9,12,13,15α-octahydrocyclo tetradeca[β]furan-2()-one (), and denticulatolide (), were isolated from the Bornean soft coral sp. Compounds and showed potential anti-inflammatory activities against lipopolysaccharide-stimulated RAW 264.7 with IC values less than 6.25 µg/mL and anticancer activity against HL60 cell lines. The compounds' mechanisms of action were investigated via the Western blot evaluation of their protein markers. These activities could be attributed to the presence of tertiary methyl at C-8 and the compounds' 3D configurations.
软珊瑚被公认为具有广泛生物活性的cembranoids 的丰富生产者。一种新的cembranoid，sinularolide F ()，以及三种已知的化合物，cembranolide ()，(,,)-6,10,14-三甲基-3-亚甲基-3α,4,5,8,9,12,13,15α-八氢环十四烷[β]呋喃-2()-one ()和 denticulatolide ()，从婆罗洲软珊瑚 sp. 中分离得到。化合物 和 对脂多糖刺激的 RAW 264.7 具有潜在的抗炎活性，IC 值小于 6.25 µg/mL，对 HL60 细胞系具有抗癌活性。通过 Western blot 评估这些化合物的蛋白标志物，研究了这些化合物的作用机制。这些活性可能归因于 C-8 位的叔甲基和化合物的 3D 构型。
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