补充鱼油对银屑病患者红细胞脂质模式、丙二醛生成及谷胱甘肽过氧化物酶活性的影响。

Effect of fish oil supplementation on erythrocyte lipid pattern, malondialdehyde production and glutathione-peroxidase activity in psoriasis.

作者信息

Corrocher R, Ferrari S, de Gironcoli M, Bassi A, Olivieri O, Guarini P, Stanzial A, Barba A L, Gregolini L

机构信息

Institute of Medical Pathology, Faculty of Medicine and Surgery, University of Verona, Italy.

出版信息

Clin Chim Acta. 1989 Feb 15;179(2):121-31. doi: 10.1016/0009-8981(89)90158-7.

DOI:10.1016/0009-8981(89)90158-7

PMID:2920445

Abstract

Erythrocytes from psoriatic patients have a significant increase in polyunsaturated fatty acids (p less than 0.001) especially in arachidonic acid (p less than 0.001). Glutathione peroxidase activity, in both erythrocytes and platelets, was stimulated when compared with normal cells (p less than 0.001, less than 0.02, respectively) and the production of malondialdehyde was also increased in psoriasis (p less than 0.01). The level of plasma selenium was significantly reduced (52.80 vs 72.49 ng/ml; p less than 0.001). alpha-Tocopherol and retinol were both normal in plasma of psoriatics. After two months of fish oil supplementation, the erythrocyte lipid pattern was changed, eicosapentaenoic and dochesaenoic acids substituting the arachidonate in the membrane. A reduction in malondialdehyde (p less than 0.01), a prolongation of bleeding time (p less than 0.05) and a further stimulation of glutathione-peroxidase (p less than 0.001) in both erythrocytes and platelets was also found.

摘要

银屑病患者红细胞中的多不饱和脂肪酸显著增加（p<0.001），尤其是花生四烯酸（p<0.001）。与正常细胞相比，红细胞和血小板中的谷胱甘肽过氧化物酶活性均受到刺激（分别为p<0.001、p<0.02），银屑病患者丙二醛的生成也增加（p<0.01）。血浆硒水平显著降低（52.80对72.49 ng/ml；p<0.001）。银屑病患者血浆中的α-生育酚和视黄醇均正常。补充鱼油两个月后，红细胞脂质模式发生变化，二十碳五烯酸和二十二碳六烯酸取代了膜中的花生四烯酸。还发现丙二醛减少（p<0.01）、出血时间延长（p<0.05），红细胞和血小板中的谷胱甘肽过氧化物酶进一步受到刺激（p<0.001）。