Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China.
Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China.
Mater Sci Eng C Mater Biol Appl. 2018 Feb 1;83:143-147. doi: 10.1016/j.msec.2017.11.009. Epub 2017 Nov 21.
Microneedle (MN) systems for painless transdermal drug delivery have been developed in the past few years to overcome the issues of hypodermic injections. This study introduces a novel dissolvable layered microneedle (LMN) with core-shell structure for efficient transdermal drug delivery. Fabricated by three-step-casting method, the LMNs encapsulated the drug into the HA layer as a "shell", which is supported by PVA layer as core and base. When the LMNs are inserted into the skin, the drug would be released immediately once the HA layer were separated or dissolved. What's more, little drug would be wasted on the residual base after insertion. It is demonstrated that the mechanical property of LMNs is kept well with 100% insertion percentage at 60% relative humidity. Moreover, in the transdermal delivery in vivo test, almost 90% of drug in LMNs could be successful delivered into the skin with 10s, while the homogeneous HA MNs with wide drug distribution need more than 120s to reach the same efficiency. Owing to the advantages of stable mechanical property and rapid efficient drug delivery, the LMNs are more reliable and satisfied for the self-administration in the future.
过去几年来，人们已经开发出微针（MN）系统，用于无痛透皮药物输送，以克服皮下注射的问题。本研究介绍了一种新型可溶解分层微针（LMN），具有核壳结构，可实现高效透皮药物输送。通过三步浇注法制造，LMN 将药物封装在 HA 层中作为“壳”，由 PVA 层作为核心和基底支撑。当 LMN 插入皮肤时，一旦 HA 层分离或溶解，药物就会立即释放。此外，插入后几乎没有药物会浪费在残留的基底上。结果表明，在 60%相对湿度下，LMN 的机械性能保持良好，插入率为 100%。此外，在体内透皮给药试验中，10s 内几乎 90%的 LMN 药物能够成功输送到皮肤中，而具有广泛药物分布的均匀 HA MN 需要 120s 以上才能达到相同的效率。由于具有稳定的机械性能和快速高效的药物输送优势，LMN 更可靠，满足未来的自我给药需求。
