用于药物输送和癌症治疗的聚酯胶束：当前的成就、进展和未来展望。
Polyester micelles for drug delivery and cancer theranostics: Current achievements, progresses and future perspectives.
机构信息
Department of Radiology, Center for Medical Imaging, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Number 17, 3rd Section, Renmin South Road, Chengdu, Sichuan 610041, China; Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
State Key Laboratory of Molecular Vaccinology, Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.
出版信息
Mater Sci Eng C Mater Biol Appl. 2018 Feb 1;83:218-232. doi: 10.1016/j.msec.2017.10.004. Epub 2017 Oct 5.
The development of tumor-targeting nanocarriers is critical important for effective treatment. The synthetic polyesters have demonstrated high potential for developing nanocarriers for cancer theranostics. Especially, the biocompatible and biodegradable polyester micelles have held great promise for cancer therapy and diagnosis, while some candidates have been translated into clinical applications or under clinical trial. In this review, we have provided the state-of-the-art of polyester micelles for drug delivery and cancer theranostics. In addition, we have summarized several major types of polyesters used in the biomedical fields, the current clinical achievements of polyester micelles and recent progresses of multi-functional polyester micelles for tumor molecular imaging and therapeutic applications.
肿瘤靶向纳米载体的发展对于有效治疗至关重要。合成聚酯在开发用于癌症治疗和诊断的纳米载体方面显示出巨大的潜力。特别是，生物相容性和可生物降解的聚酯胶束在癌症治疗和诊断方面具有很大的应用前景，其中一些候选物已经转化为临床应用或正在进行临床试验。在这篇综述中，我们提供了用于药物输送和癌症治疗的聚酯胶束的最新研究进展。此外，我们总结了几种用于生物医学领域的聚酯，介绍了聚酯胶束的当前临床成果以及多功能聚酯胶束在肿瘤分子成像和治疗应用方面的最新进展。
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