催化对映选择性合成(-)-鬼臼毒素。
Catalytic Enantioselective Synthesis of (-)-Podophyllotoxin.
机构信息
Centre of Biomedical Research (CBMR), Sanjay Gandhi Postgraduate Institute of Medical Sciences Campus , Raebareli Road, Lucknow 226014, UP, India.
Department of Chemistry, Indian Institute of Technology Kharagpur (IIT Kharagpur) , Kharagpur 721302, WB, India.
出版信息
Org Lett. 2017 Dec 15;19(24):6530-6533. doi: 10.1021/acs.orglett.7b03236. Epub 2017 Dec 6.
The first catalytic enantioselective total synthesis of (-)-podophyllotoxin is accomplished by a challenging organocatalytic cross-aldol Heck cyclization and distal stereocontrolled transfer hydrogenation in five steps from three aldehydes. Reversal of selectivity in hydrogenation led to the syntheses of other stereoisomers from the common precursor.
首次通过具有挑战性的有机催化交叉羟醛 Heck 环化和远程立体控制转移氢化反应，从三种醛出发，以五步反应完成了 (-)-鬼臼毒素的首次催化对映选择性全合成。氢化过程中选择性的反转导致从共同前体制备了其他立体异构体。
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