Centro de Investigaciones Químicas, IICBA, Universidad Autónoma del Estado de Morelos , Cuernavaca 62209, Morelos, México.
Laboratorio de Microbiología, Centro de Investigación Biomédica del Sur (IMSS) , Xochitepec 62790, Morelos, México.
J Nat Prod. 2017 Dec 22;80(12):3112-3119. doi: 10.1021/acs.jnatprod.7b00226. Epub 2017 Dec 6.
Six new compounds, aristoloxazine A (1), aristoloxazine B (2), 7-methoxytaliscanine (3), humul-7-en-1,4,11-triol (4), 8-hydroxy-β-logipinene (5), and 1β-hydroxy-4(14)-eudesmene (6), corresponding to two sulfur-containing aristoloxazines (1 and 2), an aristolactam (3), and three sesquiterpenes (4-6) were isolated, along with 26 known compounds, from the roots of Aristolochia orbicularis. The structures of the new compounds were established based on their spectroscopic and spectrometric data and in the case of aristoloxazine A (1) by single-crystal X-ray crystallography. This is the first report of sulfur-containing aristoloxazines from a natural source. Furthermore, aristoloxazine A (1) was found to possess potent in vitro antimicrobial activity against all resistant Staphylococcus aureus and several fungal strains in which it was evaluated.
从马兜铃科植物关木通的根部分离得到了 26 种已知化合物，以及 6 种新化合物，分别为：硫杂阿魏素 A（1）、硫杂阿魏素 B（2）、7-甲氧基齿叶白屈菜氨酸（3）、大麦芽酚-7-烯-1,4,11-三醇（4）、8-羟基-β-Logsipinene（5）和 1β-羟基-4(14)-桉叶烷（6）。其中包括两种含硫的阿魏素（1 和 2）、一种阿魏内酰胺（3）和三种倍半萜（4-6）。新化合物的结构是根据其光谱和光谱数据确定的，对于阿魏素 A（1），还通过单晶 X 射线晶体学进行了确定。这是首次从天然来源中分离出含硫阿魏素。此外，阿魏素 A（1）在体外对所有耐甲氧西林金黄色葡萄球菌和评估的几种真菌菌株均表现出强烈的抗菌活性。
