Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
Mar Drugs. 2017 Dec 6;15(12):381. doi: 10.3390/md15120381.
Fungi residing in mangroves are considered to be a bank of novel bioactive natural products. In the screening for bioactive metabolites from mangrove-derived fungi, the ethyl acetate extract of the fermentation broth of JRJ111048, a fungus isolated from the leaves of the mangrove plant endemic to Hainan island, was found to possess insecticidal activity against . Bioactivity-guided isolation lead to the discovery of seven metabolites -, including one new anhydride derivative aspergide (), one new lipid amide 11-methyl-11-hydroxyldodecanoic acid amide (), and five known compounds; α-ethyl glucoside (), spiculisporic acid B (), spiculisporic acid C (), spiculisporic acid (), and secospiculisporic acid B (). Their structures were established by NMR spectroscopic and MS analyses, and by comparison of previously reported data. Insecticidal activity against and antifungal activity of these compounds were investigated. As a result, the new compound showed potent insecticidal activity against newly hatched larvae of , and compound displayed weak antifungal activity against .
栖息在红树林中的真菌被认为是新型生物活性天然产物的宝库。在对红树林来源真菌产生的生物活性代谢产物进行筛选时，从海南岛特有红树林植物叶片中分离得到的真菌 JRJ111048 的发酵液的乙酸乙酯提取物被发现对具有杀虫活性。基于生物活性的分离导致发现了七种代谢产物——包括一种新的酐衍生物aspergide（）、一种新的脂酰胺 11-甲基-11-羟基十二烷酸酰胺（）和五种已知化合物；α-乙基葡萄糖苷（）、spiculisporic acid B（）、spiculisporic acid C（）、spiculisporic acid（）和 secospiculisporic acid B（）。它们的结构通过 NMR 光谱和 MS 分析以及与以前报道的数据进行比较来确定。这些化合物对 和 的杀虫活性和抗真菌活性进行了研究。结果表明，新化合物 对刚孵化的幼虫表现出很强的杀虫活性，化合物 对 显示出较弱的抗真菌活性。
