Metabolites with Insecticidal Activity from Aspergillus fumigatus JRJ111048 Isolated from Mangrove Plant Acrostichum specioum Endemic to Hainan Island.

Fungi residing in mangroves are considered to be a bank of novel bioactive natural products. In the screening for bioactive metabolites from mangrove-derived fungi, the ethyl acetate extract of the fermentation broth of JRJ111048, a fungus isolated from the leaves of the mangrove plant endemic to Hainan island, was found to possess insecticidal activity against . Bioactivity-guided isolation lead to the discovery of seven metabolites -, including one new anhydride derivative aspergide (), one new lipid amide 11-methyl-11-hydroxyldodecanoic acid amide (), and five known compounds; α-ethyl glucoside (), spiculisporic acid B (), spiculisporic acid C (), spiculisporic acid (), and secospiculisporic acid B (). Their structures were established by NMR spectroscopic and MS analyses, and by comparison of previously reported data. Insecticidal activity against and antifungal activity of these compounds were investigated. As a result, the new compound showed potent insecticidal activity against newly hatched larvae of , and compound displayed weak antifungal activity against .