Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.
Planta Med. 2013 Mar;79(5):348-52. doi: 10.1055/s-0032-1328260. Epub 2013 Mar 1.
One new flavonol, chlorflavonin A (1), four new diterpenoids, aspergiloids E-H (3, 5-7), together with eight known compounds (2, 4, 8-13) were isolated from solid fermentation of Aspergillus sp. (strain no. YXf3), an endophytic fungus from Ginkgo biloba. Their structures were determined through detailed spectroscopic analysis combined with comparison of NMR spectra data with reported ones. All of them were screened on cytotoxicity against KB, SGC-7901, SW1116, and A549 cell lines; compounds 4, 9-11 exhibited moderate activities with IC50 values ranging from 6.74 to 46.64 µM.
从银杏内生真菌 Aspergillus sp. (YXf3) 的固体发酵产物中分离得到一种新的类黄酮醇，即chlorflavonin A (1)，以及四种新的二萜类化合物，aspergiloids E-H (3, 5-7)，同时还分离得到了八种已知化合物（2, 4, 8-13）。通过详细的光谱分析，并结合 NMR 谱数据与文献报道进行比较，确定了它们的结构。对所有化合物进行了对 KB、SGC-7901、SW1116 和 A549 细胞系的细胞毒性筛选；化合物 4、9-11 表现出中等的活性，IC50 值范围为 6.74-46.64 µM。
