West K P, Cope J L
Department of Pathology, Leicester Royal Infirmary.
J Clin Pathol. 1989 Feb;42(2):140-7. doi: 10.1136/jcp.42.2.140.
The nature of endometrial glycoconjugates throughout the menstrual cycle was investigated using a panel of lectins directed against specific sugar groups. This approach was also applied to a series of endometrial adenocarcinomas the findings for which were compared with those of normal controls. A change in the expression of glycosubstances was found in relation to the phase of the menstrual cycle; that there was increasing sialylation of terminal galactose groups during the secretory phase. This change may be influenced by progesterone. One group of endometrial adenocarcinomas exhibited binding patterns similar to those seen in secretory endometrium and this may be related to progesterone receptor state. Expression of fucose containing glycosubstances was identified in half of the carcinomas but not in the normal control tissue, thus indicating that a change in fucosylation occurs with endometrial neoplasia. None of the lectin binding patterns, however, correlated with variables in the patients themselves or within the tumours.
利用一组针对特定糖基的凝集素，研究了整个月经周期中子宫内膜糖缀合物的性质。该方法也应用于一系列子宫内膜腺癌，并将其结果与正常对照的结果进行比较。发现糖物质的表达随月经周期阶段而变化；在分泌期，末端半乳糖基团的唾液酸化增加。这种变化可能受孕酮影响。一组子宫内膜腺癌表现出与分泌期子宫内膜相似的结合模式，这可能与孕酮受体状态有关。在一半的癌组织中鉴定出含岩藻糖糖物质的表达，而在正常对照组织中未发现，因此表明岩藻糖基化的变化与子宫内膜肿瘤形成有关。然而，没有一种凝集素结合模式与患者自身或肿瘤内的变量相关。
