Ko Y C, Yen Y Y, Yeh S M, Lan S J
School of Public Health, Kaohsiung Medical College, Taiwan, Republic of China.
J Med Virol. 1989 Feb;27(2):142-4. doi: 10.1002/jmv.1890270214.
Three hundred thirty-seven community-based spouses were tested for the presence of hepatitis B virus (HBV) markers to assess the direction of HBV transmission between couples. The prevalence rate of HBV infection among husbands whose wives were hepatitis B surface antigen (HBsAg)-positive was higher compared with those whose wives were HBsAg-negative. Moreover, the frequency of HBV seropositivity among husbands was 100% if their wives carried HBeAg and showed a trend correlation (P = .009). The prevalence difference was 13.8%, and the 95% confidence interval (95% Cl) was 7.9-19.7% after adjusting for spouses' age. In contrast, HBV infection rate of wives did not show an association with the husbands' HBsAg or HBeAg carrier status. The prevalence difference was 7.1%, but 95% Cl was -2.5-16.8% after adjusting for spouses' age. Female to male transmission of HBV between spouses appears to be more efficient.
对337名社区配偶进行了乙肝病毒（HBV）标志物检测，以评估夫妻间HBV传播的方向。妻子为乙肝表面抗原（HBsAg）阳性的丈夫中HBV感染率高于妻子为HBsAg阴性的丈夫。此外，如果丈夫的妻子携带HBeAg，丈夫的HBV血清阳性频率为100%，且呈趋势相关性（P = 0.009）。调整配偶年龄后，患病率差异为13.8%，95%置信区间（95%Cl）为7.9 - 19.7%。相比之下，妻子的HBV感染率与丈夫的HBsAg或HBeAg携带状态无关。患病率差异为7.1%，但调整配偶年龄后95%Cl为 - 2.5 - 16.8%。配偶间HBV从女性到男性的传播似乎更有效。
