长链非编码RNA：骨关节炎中的一种新调控密码。
Long noncoding RNAs: a new regulatory code in osteoarthritis.
作者信息
Cen Xiao, Huang Xin-Qi, Sun Wen-Tian, Liu Qing, Liu Jun
机构信息
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan UniversityChengdu, China.
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan UniversityChengdu, China.
出版信息
Am J Transl Res. 2017 Nov 15;9(11):4747-4755. eCollection 2017.
Abstract
It is reported that long noncoding RNAs (lncRNAs) were expressed aberrantly in cartilage of osteoarthritis (OA). Current evidence indicates that lncRNAs not only serve as positive or negative regulators of OA, but also crosstalk with multiple potential targets to impact on the critical events in OA process. This review summarized the lncRNAs identified in OA to date, discussed their influence on the survival of chondrocytes and synoviocytes, arthritis-associated factors, and angiogenesis, and indicated the potential in diagnosis, therapy, and prognosis.
摘要
据报道，长链非编码RNA（lncRNAs）在骨关节炎（OA）的软骨中异常表达。目前的证据表明，lncRNAs不仅作为OA的正性或负性调节因子，还与多个潜在靶点相互作用，影响OA进程中的关键事件。本综述总结了迄今为止在OA中鉴定出的lncRNAs，讨论了它们对软骨细胞和滑膜细胞存活、关节炎相关因子及血管生成的影响，并指出了其在诊断、治疗和预后方面的潜力。
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