Sun Hong, Peng Guoxuan, Ning Xu, Wang Jian, Yang Hua, Deng Jin
Department of Orthopaedics, Affiliated Hospital of Guizhou Medical University Guiyang 550004, China.
Department of Emergence Medicine, Affiliated Hospital of Guizhou Medical University Guiyang 550004, China.
Am J Transl Res. 2019 Jan 15;11(1):16-30. eCollection 2019.
Osteoarthritis (OA) is the most prevalent age-related debilitating joint disease, and is characterized primarily by articular cartilage degradation and subchondral bone lesions. It is also the leading cause of chronic morbidity in older populations. The etiology of OA is multifactorial, with the underlying regulatory mechanisms remaining largely unknown. Long noncoding RNA (lncRNA) is a group of noncoding RNAs defined as being >200 nucleotides in length. Increasing evidence demonstrates that many lncRNAs serve as critical regulators of chondrogenesis and bone and cartilage homeostasis, thereby influencing OA development. In this review, we highlight the current understanding concerning lncRNAs, including their physical features, biological functions, and potential roles in chondrogenesis, osteogenesis, and OA. This information may shed new light on the epigenetic regulation of cartilage and substantiate lncRNAs as novel therapeutic targets in OA.
骨关节炎（OA）是最常见的与年龄相关的使人衰弱的关节疾病，其主要特征是关节软骨退化和软骨下骨病变。它也是老年人群慢性发病的主要原因。OA的病因是多因素的，其潜在的调节机制在很大程度上仍不清楚。长链非编码RNA（lncRNA）是一类长度大于200个核苷酸的非编码RNA。越来越多的证据表明，许多lncRNA作为软骨形成以及骨骼和软骨稳态的关键调节因子，从而影响OA的发展。在这篇综述中，我们重点介绍了目前对lncRNA的认识，包括它们的物理特征、生物学功能以及在软骨形成、骨形成和OA中的潜在作用。这些信息可能为软骨的表观遗传调控提供新的线索，并证实lncRNA作为OA新的治疗靶点。
