Pati P C, Bhunya S P
P.G. Department of Zoology, Utkal University, Orissa, India.
Mutat Res. 1989 Mar;222(3):149-54. doi: 10.1016/0165-1218(89)90130-4.
A synthetic pyrethroid insecticide, fenvalerate, was tested for its cytogenetic effects in the mouse in vivo test system at 100, 150 and 200 mg/kg. Bone marrow metaphase analysis revealed significant increases in chromosomal aberrations in the groups treated with 150 and 200 mg/kg by intraperitoneal injection. In the micronucleus test the occurrence of PCEs with MN marginally increased with dose. Induction of PCEs with MN was significant over control again with the higher two doses. Incidence of sperm abnormalities slightly increased with dose but a significant increase was noted in all treated series over control.
一种合成拟除虫菊酯杀虫剂氰戊菊酯，在体内试验系统中以100、150和200mg/kg的剂量对小鼠进行细胞遗传学效应测试。骨髓中期分析显示，腹腔注射150和200mg/kg的组中染色体畸变显著增加。在微核试验中，含微核的嗜多染红细胞（PCEs）的发生率随剂量略有增加。较高的两个剂量组中，含微核的PCEs的诱导再次显著高于对照组。精子异常发生率随剂量略有增加，但所有处理组均显著高于对照组。
