Bhunya S P, Pati P C
P.G. Department of Zoology, Utkal University, Orissa, India.
Mutagenesis. 1990 May;5(3):229-32. doi: 10.1093/mutage/5.3.229.
The effect of the synthetic pyrethroid insecticide deltamethrin was investigated in mice in vivo for the induction of bone marrow chromosome aberrations and micronuclei in bone marrow and for sperm abnormalities. Technical deltamethrin (10, 15 and 20 mg/kg) was injected i.p. and the respective cells were fixed after 24 h, 30 h and 35 days for the observation of chromosome aberrations, micronuclei and sperm abnormalities respectively. Additionally, route-response (i.p., oral and s.c.), time-response (6, 24 and 48 h) and acute-chronic (24 versus 120 h) studies were conducted for the induction of chromosome aberrations by the highest dose (20 mg/kg) of deltamethrin. All the above test results showed significant increases over respective controls. Moreover, a linear relationship was evident between the dose of deltamethrin used and the frequencies (%) of chromosome aberrations, micronuclei or sperm abnormalities.
研究了合成拟除虫菊酯杀虫剂溴氰菊酯对小鼠体内骨髓染色体畸变、骨髓微核以及精子异常的诱导作用。将工业用溴氰菊酯（10、15和20毫克/千克）腹腔注射，分别在24小时、30小时和35天后固定相应细胞，以分别观察染色体畸变、微核和精子异常情况。此外，还针对溴氰菊酯最高剂量（20毫克/千克）诱导染色体畸变进行了途径反应（腹腔注射、口服和皮下注射）、时间反应（6、24和48小时）以及急性-慢性（24小时与120小时）研究。所有上述测试结果均显示，与各自的对照组相比有显著增加。此外，所用溴氰菊酯剂量与染色体畸变、微核或精子异常的频率（%）之间存在明显的线性关系。
