Skinnider L, Stoessl A, Wang J
Department of Pathology, University of Saskachewan, Saskatoon, Canada.
Mutat Res. 1989 Mar;222(3):167-70. doi: 10.1016/0165-1218(89)90133-x.
Dothistromin is a metabolite produced by Dothistromin pini and Cercospora arachidicola. The latter fungus is a pathogen of the peanuts and thus the mycotoxin may be a contaminant of foodstuffs. Dothistromin induces a dose-dependent increase in sister-chromatid exchange frequency in Chinese hamster ovary cells and stimulated human lymphocytes. The increased frequency in human lymphocytes seen with dothistromin is significantly higher among lymphocytes from smokers compared with those from non-smokers.
多斑曲菌素是由松生多斑曲菌和落花生尾孢菌产生的一种代谢产物。后一种真菌是花生的病原体，因此这种霉菌毒素可能是食品的污染物。多斑曲菌素会使中国仓鼠卵巢细胞和受刺激的人类淋巴细胞中的姐妹染色单体交换频率呈剂量依赖性增加。与不吸烟者的淋巴细胞相比，吸烟者淋巴细胞中多斑曲菌素导致的交换频率增加显著更高。
