Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University , Suzhou, Jiangsu 215123, China.
ACS Appl Mater Interfaces. 2018 Jan 10;10(1):332-340. doi: 10.1021/acsami.7b16890. Epub 2017 Dec 19.
Current mainstream cancer treatment methods have their limitations. New approaches are thus desired to assist our battle against cancer. Herein, multifunctional ultrasmall FeS nanodots with the size of 7 nm are synthesized by biomineralization and used for imaging-guided combined tumor therapy. Bovine serum albumin (BSA), which acts as the reaction template to induce the mineralization of FeS nanomaterials under alkaline conditions, could also be used as a drug delivery system for coupling photosensitive molecule such as Chlorin e6 (Ce6). Taking advantage of the near-infrared (NIR) absorbance and the high r relaxivity of the synthesized ultrasmall FeS nanodots, as well as the Ce6 fluorescence, in vivo trimodal imaging of optical/magnetic resonance/photoacoustics was carried out, showing efficient tumor accumulation of FeS@BSA-Ce6 after intravenous injection. In vitro and in vivo photothermal and photodynamic therapy were then conducted for synergistic tumor therapy and did not cause any apparent toxicity to the treated animals. Our work thus provides a new kind of ultrasmall FeS multifunctional nanodot modified by albumin via a simple method, promising for combination phototherapy as well as cancer theranostics.
当前主流的癌症治疗方法存在局限性。因此，我们需要新的方法来帮助我们对抗癌症。在此，我们通过生物矿化合成了尺寸为 7nm 的多功能超小 FeS 纳米点，并将其用于成像引导的联合肿瘤治疗。牛血清白蛋白（BSA）不仅可以作为反应模板，在碱性条件下诱导 FeS 纳米材料的矿化，还可以作为光敏分子如 Chlorin e6（Ce6）的药物输送系统。利用合成的超小 FeS 纳米点的近红外（NIR）吸收和高 r 弛豫率，以及 Ce6 的荧光，进行了体内光学/磁共振/光声三模态成像，显示静脉注射后 FeS@BSA-Ce6 高效地聚集在肿瘤部位。随后进行了体外和体内的光热和光动力治疗，实现了协同肿瘤治疗，且对治疗的动物没有造成明显的毒性。我们的工作因此提供了一种通过简单方法修饰的新型超小 FeS 多功能白蛋白纳米点，有望用于联合光疗以及癌症的诊断与治疗。
