Department of Microbiology, Nihon University School of Dentistry, Tokyo 101-8310, Japan; Immersion Physics Class, Department of Science, Tokyo Gakugei University International Secondary School, Tokyo 178-0063, Japan.
Immersion Physics Class, Department of Science, Tokyo Gakugei University International Secondary School, Tokyo 178-0063, Japan.
J Mol Graph Model. 2018 Jan;79:185-191. doi: 10.1016/j.jmgm.2017.11.013. Epub 2017 Nov 28.
Avian influenza viruses easily spread allowing viral re-assortment to simply occur which in-turn increases the potential for a pandemic. A novel 2013 H5N6 influenza strain was detected among the avian population and was reported to continuously evolve, however, this was never structurally demonstrated. Here, we elucidated the putative structural evolution of the novel H5N6 influenza strain. Throughout this study, we analyzed 2013-2017 H5N6 HA protein models. Model quality was first verified before further analyses and structural comparison was made using superimposition. We found that Leu was inserted at position 129 among the 2013-2015 models while Leu was not inserted among the 2016-2017 models. Moreover, presence of Leu at position 129 shifts residue E126 by 159.6° affecting nearby residues which may explain the difference between the 2013-2015 and 2016-2017 HA structural groups. Similarly, we believe that our results would support the hypothesis that the current H5N6 strain is still continuously evolving.
禽流感病毒容易传播，导致病毒重组很容易发生，从而增加了大流行的可能性。在禽类中检测到一种新型的 2013 年 H5N6 流感株，并报告其持续进化，但从未从结构上证明这一点。在这里，我们阐明了新型 H5N6 流感株的假定结构进化。在整个研究过程中，我们分析了 2013-2017 年 H5N6 HA 蛋白模型。在进行进一步的分析和结构比较之前，首先验证了模型质量，使用叠加进行了比较。我们发现，2013-2015 年的模型中在位置 129 插入了亮氨酸，而在 2016-2017 年的模型中没有插入亮氨酸。此外，位置 129 处亮氨酸的存在使残基 E126 发生 159.6°的位移，影响了附近的残基，这可能解释了 2013-2015 年和 2016-2017 年 HA 结构组之间的差异。同样，我们相信我们的结果将支持当前 H5N6 株仍在持续进化的假设。
