一种新型低分子量浒苔多糖-铁（III）配合物及其对缺铁性贫血（IDA）大鼠的作用。
A novel low molecular weight Enteromorpha polysaccharide-iron (III) complex and its effect on rats with iron deficiency anemia (IDA).
机构信息
College of Food Science and Engineering, Ocean University of China, Qingdao 266003, PR China.
College of Food Science and Engineering, Ocean University of China, Qingdao 266003, PR China; State Key Laboratory of Bioactive Seaweed Substances, Qingdao 266400, PR China.
出版信息
Int J Biol Macromol. 2018 Mar;108:412-418. doi: 10.1016/j.ijbiomac.2017.12.033. Epub 2017 Dec 6.
Iron deficiency anemia (IDA) is a common nutritional disease that affects normal erythropoiesis. Traditional iron supplements usually cause gastrointestinal irritation. In this study, a novel low-molecular-weight polysaccharide from Enteromorpha prolifera (LPE) was prepared by oxidation degradation, and LPE-iron (III) complex was synthesized and characterized. The molecular weight of LPE-iron (III) complex was 21.25kDa, and iron content was 25%. The therapeutic effects of LPE-iron (III) complex on IDA were investigated in rats. The hematological indices and organ coefficients of the rats were analyzed. Results showed a dose-dependent relationship, and a prior intragastric administration of LPE-iron (III) complex (2mg Fe/kg body weight) exhibited considerable effect when compared with the positive control. Therefore, LPE-iron (III) complex could be exploited as a new iron fortifier.
缺铁性贫血（IDA）是一种常见的营养性疾病，影响正常的红细胞生成。传统的铁补充剂通常会引起胃肠道刺激。本研究通过氧化降解制备了一种新型的浒苔低分子量多糖（LPE），并合成和表征了 LPE-铁（III）配合物。LPE-铁（III）配合物的分子量为 21.25kDa，铁含量为 25%。研究了 LPE-铁（III）配合物对 IDA 大鼠的治疗作用，分析了大鼠的血液学指标和器官系数。结果显示存在剂量依赖性关系，与阳性对照相比，预先经胃内给予 LPE-铁（III）配合物（2mg Fe/kg 体重）具有显著效果。因此，LPE-铁（III）配合物可用作新型铁强化剂。
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