从人类感染中分离出的一株超黏液/超毒力且耐多药 CTX-M-15/K19/ST29 型肺炎克雷伯菌的基因组序列分析。
Genome sequence analysis of a hypermucoviscous/hypervirulent and MDR CTX-M-15/K19/ST29 Klebsiella pneumoniae isolated from human infection.
机构信息
Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, CEP 05508-000, Brazil.
Department of Clinical Analysis, School of Pharmacy, University of São Paulo, São Paulo, CEP 05508-000, Brazil.
出版信息
Pathog Dis. 2017 Dec 29;75(9). doi: 10.1093/femspd/ftx121.
The emergence of hypervirulent Klebsiella pneumoniae (hvKP) with multidrug resistance (MDR) profile is a worrisome public health issue. We report the first draft genome sequence of a hypermucoviscous (positive string test) and MDR K. pneumoniae serotype K19, belonging to ST29, isolated from human infection. This strain harboured multiple antimicrobial resistance genes, including blaCTX-M-15, besides yersiniabactin and type 3 fimbriae virulence genes. In vivo experiments carried out with the Galleria mellonella infection model revealed that K. pneumoniae K19/ST29 killed 100% of the larvae at 24 h post-infection, in a similar way to the known hypermucoviscous hvKP K1/ST23 lineage.
产超广谱β-内酰胺酶（ESBL）的高毒力肺炎克雷伯菌（hvKP）具有多重耐药（MDR）表型，是一个令人担忧的公共卫生问题。我们报告了首例从人类感染中分离出的超黏液型（胶状试验阳性）和 MDR 型肺炎克雷伯菌血清型 K19，其 ST29 型的首个基因组草案序列。该菌株携带多种抗生素耐药基因，包括 blaCTX-M-15，此外还有耶尔森菌生物素和 3 型菌毛毒力基因。在使用大蜡螟感染模型进行的体内实验中，肺炎克雷伯菌 K19/ST29 在感染后 24 小时内以类似于已知的超黏液型高毒力 hvKP K1/ST23 谱系的方式杀死了 100%的幼虫。
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